Ref : 395
Title : Comparative study of asymmetric nuclear matter using extended BHF with different three-nucleon force models
Author(s) :
Name : Khaled S. A. Hassaneen
Address : Physics Department, Faculty of Science, Sohag University, Sohag, Egypt
   
Name : Khaled S. A. Hassaneen
Address : Physics Department, Faculty of Science, Sohag University, Sohag, Egypt
   
Name : Hoda M. Abou-Elsebaa
Address : Physics Department, Faculty of Science, Sohag University, Sohag, Egypt
   
Accepted : 7/31/2016 3:36:00 PM    
Abstract :
We calculate the energy per nucleon of asymmetric nuclear matter using the microscopic many-body Brueckner-Hartree-Fock (BHF) approach and employing the CD-Bonn and Argonne V18 nucleon-nucleon (NN) potentials supplemented with three different types of three-nucleon force (TNF) models. These models are constructed to reproduce the experimental value of binding energy of symmetric nuclear matter. In addition, TNFs are likely crucial in the case of dense β-stable nuclear matter to obtain a stiff equation of state (EOS) to reproduce the maximum mass of the neutron stars compatible with the measured experimental value.

Ref : 392
Title : Recent Trends in Antimicrobial Polymers
Author(s) :
Name : El-Refaie Kenawy
Address : Department of Chemistry, Polymer Reserch Group, Faculty of Science, University of Tanta, Tanta, EGYPT
   
Accepted : 7/23/2016 11:04:00 AM    
Abstract :
Microbial infection remains one of the most serious complications in several areas. Particularly in medical devices, drugs, health care and hygienic applications, water purification systems, hospital and dental surgery equipment, textiles, food packaging and food storage. Antimicrobials gain interest from both the academic research and industry due to their potential to provide quality and safety benefits to many materials. However, low molecular weight antimicrobial agents suffer from so many disadvantages such as toxicity to the environment, and short-term antimicrobial ability. To overcome problems associated with the low molecular weight antimicrobial agents, they are prepared by introducing antimicrobial functional groups into the polymer molecules. The use of antimicrobial polymers offers promise for enhancing the efficacy of some existing antimicrobial agents and minimizing the environmental problems accompanying conventional antimicrobial agents by reducing the residual toxicity of the agents, increasing their efficiency and selectivity, and prolonging the
lifetime of the antimicrobial agents. Research concerning the development of antimicrobial polymer represents a great a challenge for both academic world and industry. This lecture reviews the state of the art of the antimicrobial polymers. In particular, it is discussing the requirements of antimicrobial polymers, factors affecting the antimicrobial activities, methods of synthesizing antimicrobial polymers, major fields of applications and future and perspectives in the field of antimicrobial polymers. The lecture will be based on my reviews and book chapters in the topic.

Ref : 391
Title : Synthesis and Characterization of novel Carbazole-based Block copolymer for applications in solar cells
Author(s) :
Name : Abdelqader Imragaa
Address : Department of Chemistry, University of Benghazi, Benghazi, Libya.
   
Name : Abdulaziz Ali B. Alghamdi
Address : Department of Chemistry, King Saud University, Riyadh 11451, Saudi Arabia.
   
Name : Ahmed Iraqi
Address : Department of Chemistry, University of Sheffield, Sheffield S3 7HF, UK.
   
Accepted : 7/21/2016 10:25:00 AM    
Abstract :
Research in organic materials for application in organic solar cells has increased in recent years. Organic solar cells have many advantages when compared with inorganic solar cells. The organic solar cells offer low cost, flexible substrates, very high speed of processing. The focus of the work is development and characterization the new low band gap polymer. These low band gap polymers can then be mixed with fullerenes derivatives such as PCBM to make bulk heterojunction devices. The polymer have been synthesised for applications in solar cells. donor/acceptor carbazole block copolymer comprising alternating poly(3,6-difluoro-9-(1-octyl- nonyl)-9H-carbazole-2,7-diyl-alt-(5,7-di-2-thienyl-2,3-bis-[4-(2-ethyl-hexyloxy)- phenyl]-thieno[3,4-b]pyrazine)-5,5-diyl)-alt-2,2’-(5,5’-bithienylene)]) P1. Block copolymer P1 have been synthesised following Suzuki cross coupling polymerisation methods. The polymer were characterised by 1 H NMR, 13 C NMR and Elemental Analysis. Molecular weights were estimated using gel permeation chromatography (GPC). The thermal stability behaviour for polymers was investigated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The photophysical and electronic properties were investigated using UV-Vis spectroscopy and cyclic voltammetry (CV). Electrochemical and optical absorption show that the band gaps for P1 is 1.58 eV 1-6 .
Reference
[1] Peet, J.; Kim, J. Y.; Coates, N. E.; Ma, W. L.; Moses, D.; Heeger, A. J.; Bazan, G. C. Nat. Mater. 2007, 6, 497.
[2] Kim, J. Y.; Lee, K.; Coates, N. E.; Moses, D.; Nguyen, T.-Q.; Dante, M.; Heeger, A. J. Science 2007, 317, 222.
[3] Park, S. H.; Roy, A.; Beaupre, S.; Cho, S.; Coates, N.; Moon, J. S.;Moses, D.; Leclerc, M.; Lee, K.; Heeger, A. J. Nat. Photonics 2009, 3, 297.
[4] Y. liang.; J. B. Xia.; S. Tasi.; Z. Xu.; G. Li.; C. Ray.; L. Yu., Adv. Mater 2010, 22, E135-E138
[5] Abdulaziz Ali B. Alghamdi1 , Abdelqader Imragaa, Essam S. Abdel-Halim1 and Ahmed Iraqi ., Int. J. Electrochem. Sci., 11 (2016) 5111 – 5127
[6] Abdelqader Imragaa, Fateh B. Eltaboni, Khaled Edbey, Abdelkarem A. Elgazail, Abdulaziz Al Ghamdi and Ahmed Iraqi, Physical Science International Journal 10(2): 1-8, 2016

Ref : 390
Title : Astrochemistry: New Window of Research in Egypt
Author(s) :
Name : Zainab M. Awad
Address : Astronomy, Space Science, & Meteorology, Faculty of Science, Cairo University
   
Accepted : 7/19/2016 2:09:00 PM    
Abstract :
Astrochemistry is the science that blinds chemistry and astronomy. It started with the discovery of the first molecules, CH, CH+, and CN, in the interstellar medium in 1940s. Thanks to the new development of technologies that allowed us to observe more species in several astrophysical environments. In order to understand the chemical processes that led to the formation and/or destruction of these interstellar species, it is important to understand the physical conditions of the region understudy. Several theoretical and experimental studies are performed and in progress to understand the chemical processes in astronomical environments.
In this paper, I review the main chemical processes in the interstellar medium and the chemical modeling of some astrophysical regions. I, also, show how Egyptian scientists can collaborate to conduct research in such new field.

Ref : 389
Title : New Hyperbranched Chitosan-Manganese Oxide Nanoparticles Modified Screen Printed Electrode for the Direct Electrochemical Detection of Glucose
Author(s) :
Name : Hala S. Abd El-Haleem, Amr Hefnawy, Rabeay Y. A. Hassan, Ibrahim M. El-Sherbiny
Address : 1Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science and Technology, 6th October City, 12588 Giza, Egypt, 2Microanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre (NRC), Dokki, 12622, Giza, Egypt
   
Accepted : 7/15/2016 6:26:00 PM    
Abstract :
In the present study, we report the synthesis and characterization of several polymeric nanocomposites using different metals and metal oxides nanoparticles. The nanocomposites were tested and utilized for the direct biosensing of glucose. Among them, a newly synthesized core-shell hyperbranched chitosan-manganese oxide (HBCs-MnO2) nanocomposite showed the highest sensitivity. This HBCs-MnO2 nanocomposite was selected for surface modification of the screen printed-3 electrode system followed by immobilization of glucose oxidase (GOx). Assay optimization was achieved after testing the effects of several factors such as type of crosslinking agent, accumulation potential, toxicity of heavy metals and interferences on the bioactivity of GOx. The results demonstrated that the proposed method was sensitive to detect inhibition effects of metal ions and also the response of interfering agents such as acetaminophen (paracetamol) which interfered with the glucose measurement. Eventually, chronoamperometric calibration curve was obtained, and the oxidation current of the enzymatically produced hydrogen peroxide was linearly dependent on the glucose concentration (from 28 µg/ml to 93 µg/ml) with a limit of detection of 7 µg/ml. Clinical determination of glucose concentration was successfully performed on blood samples and the results were correlated with a reference method. In conclusion, the current study suggests a new class of electrochemical biosensors and paves the way for further promising applications.

Ref : 388
Title : Development of DOX-loaded Alginate/Chitosan core/shell nanoparticles for intranasal brain delivery: Optimization, Evaluation, cytotoxicity and in-vivo biodistribution
Author(s) :
Name : Amr Hefnawy, Islam A. Khalil, Ibrahim M. El-Sherbiny
Address : [1] Center for Materials Science, Zewail City of Science and Technology [2] Misr University for Science and Technology
   
Accepted : 7/15/2016 6:26:00 PM    
Abstract :
In this study, the development of novel Doxorubicin/Alginate/Chitosan nanoparticles is described. These were synthesized using a simple process of few steps. The synthetic process has been optimized to improve the particle size, charge, release profile and entrapment efficiency. These nanoparticles were in turn loaded into PVP nanofibers that were terminally loaded into a nasal insert. This formulation aims at providing selective delivery through the intranasal route to the brain for treatment of brain tumors. The cytotoxicity of the prepared formulation was tested on cancer lines as well as normal cells. The size of the prepared nanoparticles was in the range of 300 – 350 nm which is optimum for passive targeting of tumors based on the enhanced permeability and retention effect. The particles were also designed to have positive charge to improve intracellular uptake into the cancer cells. This system also provided excellent entrapment efficiency if about 80 – 90% and extended release profile for around 6 days. The role of the nanofiber is to provide optimum adhesion to the nasal cavity for a suitable duration to allow significant drug absorption.

Ref : 387
Title : Reduced graphene oxide-hyperbranched chitosan-based microbial sensor for direct electrochemical detection of E. coli
Author(s) :
Name : Mohammed Sedki, Amr Hefnawy, Rabeay Y. A. Hassan, Ibrahim M. El-Sherbiny,
Address : 1Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science and Technology, 6th October City, 12588 Giza, Egypt, 2Microanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre (NRC), Dokki, 12622, Giza, Egypt
   
Accepted : 7/15/2016 6:26:00 PM    
Abstract :
Microbial biosensors are of a great importance in detection and identification of pathogens to prevent propagation of infectious diseases. A new hybrid nanosystem of reduced graphene oxide-hyperbranched chitosan (rGO-HBCs), as a working electrode in electrochemical detection of E. coli, is introduced. The size, morphology and chemical composition of the as-prepared nanomaterials are described. In addition, the cell viability of E. coli was monitored by measuring the oxidation current of metabolic activity of viable cells. Consequently, few bioelectrochemical factors, such as cell viability, type of nutritious carbon source, sensing time and scan rate have been studied. Moreover, the response of E. coli to Simvastatin (antibiotic) has been investigated. Finally, the presented assay works efficiently in monitoring the growth rate and cell viability of micro-organisms.

Ref : 386
Title : Core-Shell Hyperbranched Chitosan-based Nanostructure as a Novel Natural Redox Polymer
Author(s) :
Name : Mohammed Sedki, Amr Hefnawy, Rabeay Y. A. Hassan, Ibrahim M. El-Sherbiny
Address : 1Nanomaterials Laboratory, Center for Materials Science, Zewail City of Science and Technology, 6th October City, 12588 Giza, Egypt, 2Microanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre (NRC), Dokki, 12622, Giza, Egypt
   
Accepted : 7/15/2016 6:26:00 PM    
Abstract :
In the present study, we report, for the first time, the development and use of core-shell amino-terminated chitosan-based hyperbranched nanoparticles (HBCs-NH2 NPs) as a novel natural polymer-based self-mediated redox modifier for efficient electrochemical systems. Using ferricyanide (FCN) as the redox probe, the electrochemical activity of the developed HBCs-NH2 NPs as compared to chitosan (Cs) NPs was investigated. The oxidation peak height was about twofold higher than the response of Cs-modified electrode. On the other hand, NADH oxidation at the nanostructured surfaces confirmed the electrocatalytic activity where the oxidation of NADH appeared at a lower overpotential (from 805 mV to 635 mV vs Ag/AgCl). Eventually, a diffusion-controlled process was confirmed from the scan rate effect.

Ref : 385
Title : Phenytoin/Lecithin Nanofibers loaded with Phenytoin/Sildenafil Double Therapy as a Potential Wound Dressing and Scaffolding Material for Skin Tissue Regeneration
Author(s) :
Name : Isra H. Ali
Address : Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12588, Egypt,
   
Name : Islam A. Khalil
Address : 1 Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12588, Egypt, 2 Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy and Drug Manufacturing, Misr University of Science and Technology (MUST), 6th of October, Giza 12566, Egypt.
   
Name : Ibrahim M. El-Sherbiny
Address : Nanomaterials Lab, Center of Material Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12588, Egypt
   
Accepted : 7/15/2016 3:14:00 PM    
Abstract :
Purpose: Skin is the soft organ that is responsible for protecting the anterior body organs from the surrounding environment. Skin has the capability of self-healing after injuries and burns, however well-restoration and orientation of growing cells is not granted. Hence, a scaffolding material is mandatory for stimulating well restoration and organization of the regenerated growing cells. Nanofibers have been reported to be ideal scaffolds due to their high porosity and dimensions that resemble tissues natures inside our body that allow normal oxygen and nutrient diffusion. This study aims at fabricating of PLLA/Lecithin Nanofibers loaded with Phenytoin and Sildenafil separately in consecutive two layers to be used as a wound dressing and skin regenerating scaffold material.
Methods: Unloaded PLLA nanofibers, Phenytoin loaded PLLA nanofibers, Sildenafil loaded PLLA nanofibers, Phenytoin loaded PLLA/Lecithin and Sildenafil loaded PLLA/Lecithin nanofibers were fabricated used electrospinning technique. Electrospinning parameters were tailored in order to develop uniform highly porous nanofibrous matrices to maintain high perfusion of oxygen and nutrients among growing cells. Drug loaded matrices were tested for their in vitro release to examine the sustaining ability of the developed nanofibers. Scanning electron microscope revealed developed nanofibers morphology. In addition, complete physicochemical characterization was done before starting the in vivo testing on mice animal model.
Results: SEM confirmed the successful formation of uniform highly porous nanofibrous matrices possessing nanofibers dimensions less than 300 nm as shown in Figure 1. In vitro drug release showed that PLLA/Lecithin nanofibers could release the drug in around 10 days which is more convenient for wound treatment when compared to PLLA nanofibers that would extend the release to more than 3 weeks. This would consequently lead to extremely slow healing process. In vitro biodegradability showed that the nanofibers lose more than 25% of their weight in 14 days, while the swelling experiment revealed that the nanofibers showed maximum swelling after only 6 hours where their initial weight increased by 50-60%.

Ref : 384
Title : Microwave-assisted one-pot three component regioselective synthesis of novel bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-ones)
Author(s) :
Name : Nesma A. Abd El-Fatah, Ahmed F. Darweesh, Ahmed H. M. Elwahy, and Ismail A. Abdelhamid
Address : Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
   
Accepted : 7/15/2016 10:34:00 AM    
Abstract :

Heterocycles containing the 1,2,4-triazole nucleus exhibit various biological activities, and several of them have been used as fungicidal, bactericidal, insecticidal, antitumor and anti-inflammatory agents.1 Moreover, some 1,2,4-triazolo[5,1-b]quinazolinones have been reported to exhibit good antifungal, antihistaminic and antirheumatic activities.2 Furtheremore, bis-heterocyclic compounds were found to have various applications,3 and recent reports demonstrated that among libraries of derivatized heterocycles, the most active library compounds had a bis-heterocyclic structure.4 In connection with these findings, we report here an efficient and convenient route for the regioselective synthesis of novel bis(1,2,4-triazolo[5,1-b]quinazolinones) 2. The synthetic pathway involves one pot, multi-component reaction of bis-aldehydes 1, 1,2,4-triazole and dimedone in the presence of catalytic amount of DMF under microwave irradiation. Structural assignment of the obtained regioisomers was determined utilizing 2D 15N-NMR techniques as a valuable tool.
References
1. Kathiravan M. K., Salake A. B., Chothe A. S., Dudhe P. B., Watode R. P., Mukta M. S., Gadhwe S. Bioorg. Med. Chem. 2012, 20,5678–5698.
2. Alagarsamy, V.; Solomon, V. R.; Murugan, M. Bioorg. Med. Chem. 2007, 15, 4009–4015.
3. Murru, S.; Nefzi, A. ACS Comb. Sci. 2014, 16, 39-45.
4. Soural, M.; Bouillon, I.; Krchnak, V. J. Comb. Chem. 2008, 10, 923-933.

Ref : 383
Title : Synthesis of New Heterocyclic Aromatic Compounds Containing Nitrogen and Sulfur Atoms, and Their Anti-Microbial Studies
Author(s) :
Name : Eman A. El Rady
Address : Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
   
Accepted : 7/14/2016 6:15:00 AM    
Abstract :
1-(2-chloroacetyl chloride)thiourea 1 has been synthesized and reacted with some selected active methylene derivatives such as diethylmalonate, acetyl acetone, malononitrile, ethyl cyanoacetate and cyanoacetamide, compound 1 also investigated towards some selected amino nucleophilic reagents such as hydrazine hydrate, phenyl hydrazine, urea, thiourea, and 2-phenylenediamine in triethyl amine solution to afford new new five-, six- and seven-membered heterocyclic compounds.

Ref : 382
Title : Smart Soft Nanomaterials for Biomedical Applications: An Overview and Progress
Author(s) :
Name : Ibrahim M. El-Sherbiny
Address : Professor of Nano and Materials Science, Director of Center for Materials Science University of Science and Technology (UST), Zewail City
   
Accepted : 7/14/2016 6:24:00 AM    
Abstract :
Soft materials have received a considerable interest as leading candidates for controlled drug delivery, gene delivery, regenerative medicine, and engineered tissue scaffolds due to their unique compositional and structural similarities to natural tissues, in addition to their desirable framework for cellular proliferation and survival. Smart (stimuli-responsive) soft materials, a significant class of soft materials, are three-dimensional networks that are able to dramatically change their size and other characteristics in response to environmental stimuli such as pH, temperature, magnetic field, electricity, light and certain chemicals. More recently, the ability to control the size in the nanoscale, shape, porosity, and surface morphology of soft matrices has created new opportunities to overcome various challenges in different applications. In addition, the concurrent rapid and significant stimuli-response and high elasticity of these nano-structured smart soft materials may expand the scope of their applications, and provide enhanced performance in their uses especially in the biomedical field. The talk will provide an overview of the advances in nanotechnology, different types of materials with emphasis on the smart types, the approaches that can be used to fabricate their nano-matrices with specific features and their recent applications in targeted and sustained drug delivery, gene delivery, stem cell research, tissue engineering, and some other biomedical and dental applications.

Ref : 381
Title : Synthesis and Characterization of Copper(II) Complexes Containing N3S2 donors Ligand. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity
Author(s) :
Name : Asmaa Mustafa,
Address : aChemistry Department, Faculty of Science, Kafr El-Sheikh University, Kafr El-Sheikh Egypt bChemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
   
Name : Abd El-Motaleb M. Ramadana, Asmaa Ibrahium, Magda Abd El-Azizb and
Address : aChemistry Department, Faculty of Science, Kafr El-Sheikh University, Kafr El-Sheikh Egypt bChemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
   
Accepted : 7/13/2016 12:15:00 PM    
Abstract :
The reaction of the pyridine based ligand, L, with copper(II) salts (CuX2; X = Cl¯, Br¯, NO3¯, AcO¯ and ClO4¯) in a 1:1 ratio in ethanol gives a series of copper(II) complexes having the molecular formulae of [CuLX]X (X = Cl, Br, NO3) and [CuL]X2 (X = AcO and ClO4). Structural characterization of the pure isolated complex species was achieved by several physicochemical methods, namely elemental analysis, electronic spectra, IR, ESR, molar conductivity, thermal analysis (TAG & DTG), and magnetic moment measurements. The stereochemistry, the nature of the copper(II) chelates, and the catalytic reactivity are markedly dependent upon the type of counter anions incorporated in the complex molecule. Mimicking copper-oxidase enzymes namely catechol oxidase and phenoxazinone synthase was investigated and the results obtained demonstrated that, there is a correlation between the structural properties of these copper(II) complexes and the oxidase biomimetic catalytic activities. Catalytic studies demonstrate that the reported copper(II) complexes are suitable as catalysts for the catalytic aerobic oxidation of 3,5-di-tert-butylcatechol (3,5-DTBCH2) to 3,5-di-tert-butyl-benzoquinone (3,5-DTBQ) (catechol oxidase activity), and o-aminophenol (OAPH) to 2-aminophenoxazine-3-one (APX) (phenoxazinone synthase activity) with dioxygen at ambient condition in good yields. The probable mechanistic implications of both catalytic systems are discussed.

Ref : 380
Title : Multicomponent Synthesis and Some Reactions of 2-Amino-1-(4-methylphenyl)-5-Oxo-1,4,5,6,7,8- Hexahydroquinoline-3-Carbonitrile Derivatives
Author(s) :
Name : Omyma A. AbdAllah*,Antar A. AbdElhamed and Asmaa H. A. Tamam
Address : Chemistry Department, Faculty of Science, Sohag University, Sohag , Egypt
   
Accepted : 7/13/2016 6:33:00 AM    
Abstract :
Hexahydroquinoline and its derivatives were found to possess several pharmacolgical properties, including analgesic, cardiovascular, anti-malarial, -cancer, -bacterial, -plasmodial, -inflammatory, -fungal, and -viral activities.
Searching for compounds with different pharmaceutical activities, the synthesis of new series of hexahydroquinoline derivatives as shown in the following scheme has been reported in this work. Compounds 1 was used as the starting material for the preparation of new series of polyfused hexahydroquinolines via the reaction with different reagents exemplified by acetic anhydride, N,N-dimethylformamide-dimethylacetal (DMF-DMA) and 2,5-dimethoxytetra- hydrofurane to form compounds 2-4, respectively.The structures of the prepared compounds were confirmed by different spectral analyses.
References
1. Shaaban K. Mohamed, Mehmet Akkurt, Jerry P. Jasinski , Omyma A. Abd Allah, and Mustafa R. Albayati; Acta Crystallographica Section E, November (2015), E71, 0949-0950, doi:101107/s 205698901502131


Ref : 379
Title : Structural and Photocatalytic of MCM Doped ZnO Nanoparticles, and It’s Application in Removal of Iron, Cadmium and Lead Ions from Water
Author(s) :
Name : Shady M. eldafrawy
Address : samia el gamal mansoura egypt
   
Accepted : 7/13/2016 6:33:00 AM    
Abstract :
MCM doped ZnO catalysts were synthesized by sol-gel technique, the prepared samples were characterized by X-ray diffraction, the surface acidity of the prepared catalysts was measured by n-butylamine method. The photo catalytic activity of the samples was tested using the degradation of Methylene Blue (MB) under UV light as model reaction and flame atomic absorption used to determine the investigated heavy metal concentration. The MCM/ZnO molar ratio was varied in order to study its influence on the photo efficiency of the samples. 0.05 MCM/ZnO catalysts showed higher photo activity than the pure ZnO sample. The high activity of the mixed oxide samples was attributed to the presence of hetero junctions between the two oxides, which allows an improved charge separation of the photo generated electron-hole pairs, due to the differences between the energy levels of the conduction and valence bands of MCM and ZnO. Compared with pure ZnO, 100% efficiency was obtained by the MCM-doping.
Keywords

ZnO; Nanocomposite; Photoefficiency; Methylene Blue (MB)

Ref : 378
Title : Modified Vanadium Oxide Supported Zirconia as Catalyst for Catalytic Synthesis of Coumarin
Author(s) :
Name : Soad Abd Elmounem Sallam
Address : Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
   
Name : Shawky Abd Elwahab Elshazly
Address : Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
   
Name : Awad Ibrahim Ahmed
Address : Chemistrydepartment, Faculty of Science, Mansora University, Mansora, Egypt
   
Accepted : 7/12/2016 10:00:00 AM    
Abstract :
The present research work studied the effect of addition of vanadium oxide in different proportions (1, 3, 7, 10, 20 and 30 wt. %) by impregnation method to sulfated polymer zirconia. The prepared samples were calcined at 400, 500, 600 and 750C for 3h. The structural properties of these catalytic materials were studied by thermal analysis, X-ray diffraction and gas adsorption. The surface acidity of the investigated catalysts was determined by titration with n-butyl amine. Thermal analysis revealed the formation of zirconium oxide phase. The presence of vanadium oxide on the surface of zirconia catalyst was found to affect the temperature at which crystallization of zirconia takes place. X-ray analysis of the catalytic materials indicated the presence of a mixture of monoclinic and tetragonal zirconia which were formed after calcination at temperatures > 500C. The percentage of tetragonal phase was found to decrease with the increase of vanadium content and with the increase of the calcination temperature. After calcination at temperature as high as 600C, the amount of tetragonal phase is reduced. The surface area of the investigated catalysts was influenced with V2O5 content and the calcination temperature. Crystallite size was found to increase with the increase of the calcination temperature. The acidity studies demonstrated the presence of a mixture of Bronsted and Lewis acid sites. The total acidity of the investigated catalysts was influenced with both the calcination temperature and the vanadium oxide loading. The catalytic activity of the investigated catalysts was influenced strongly with the structural properties and surface acidity of the catalysts.

Ref : 376
Title : Utility of platinum and screen printed electrodes for microdetermination of the hypoglycemic drug gliclazide via cyclic voltammetry.
Author(s) :
Name : Eman Y. Z. Frag
Address : Faculty of science, Cairo university, Chemistry department.
   
Name : Reham H. Tammam
Address : Faculty of science, Cairo university, Chemistry department.
   
Name : Rahenda H. Mohammad
Address : Faculty of science, Cairo university, Chemistry department.
   
Name : Gehad G. Mohamed
Address : Faculty of science, Cairo university, Chemistry department.
   
Accepted : 7/11/2016 5:47:00 PM    
Abstract :
Gliclazide the hypoglycemic drug was determined via simple and accurate electrochemical method based on cyclic voltammetry. The method was based on the oxidation of gliclazide under different conditions to obtain the optimum state for its quantitative determination. The electrochemical behavior of 1.0×10-3 mole L-1 gliclazide was studied using platinum and screen printed electrodes in different buffers at pH 7 (acetate buffer was selected to undergo the full study). The oxidation behavior of gliclazide was studied in acetate buffer over the pH range of 3-11 and at different scan rates ranging from 10 to 100 mV s-1. The calibration graphs showed linearity over the concentration range 1.0×10-3 -1.0×10-6 mole L-1. The method was applied on the tablet dosage forms for which inter- and intra-day measurements were carried out and statistical data showed high accuracy and precision of the proposed method. The results obtained were compared with the official method.
Keywords: Gliclazide, platinum electrode, screen printed electrode, cyclic voltammetry.

Ref : 375
Title : Sorption of iodine on ion exchange resins
Author(s) :
Name : Noha S. Farahat
Address : Atomic Energy Authority, Radiation Protection Department, Nuclear research Center. Cairo 13759,Egypt
   
Name : Nariman H. M. Kamel
Address : Atomic Energy Authority, Radiation Protection Department, Nuclear research Center. Cairo 13759
   
Name : Mohammed R. Shehata
Address : Chemistry Department, Faculty of Science, Cairo University, Giza 12613. Egypt
   
Accepted : 7/10/2016 2:06:00 PM    
Abstract :
The objective of this work is to determine sorption capacity of inexpensive ion exchange resins for medically (131I) isotope. Biorex-5 is anion exchange resin having a highly sorption capacity for iodine, it used for separation of iodide radioactive isotope (131I) from nuclear waste product and for pharmatheutical uses. Sorption capacity of inexpensive synthetic PGMA and commercial Dowex 1-8X resins was compared with Biorex-5 resin. Infra red spectroscopy and SEM morphology determined for the resin samples before and after iodine adsorption. The dry capacity of the Biorex-5, Dowex 1-8X and PGMA resins was determined by the titration method, it was found between 2.5 and 8.6 eq/g. Kinetic data was fitted to pseudo second order equation. Sorption isotherm was fitted to Langmuir equation.

Keywords: iodide, PGMA, sorption, capacity, isotherm, kinetics, (Kd), electrical potential

Ref : 374
Title : Preparation and spectroscopic studies on charge-transfer complexes of 1,4,7,10,13,16-hexamethyl-1,4,7,10,13,16-hexaazacyclodecane with different acceptors
Author(s) :
Name : Akmal S. Gaballa
Address : Faculty of Specific Education, Zagazig University, Zagazig, Egypt
   
Name : S.M. Teleb
Address : Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
   
Name : E.M. Nour
Address : Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
   
Accepted : 7/10/2016 2:06:00 PM    
Abstract :
Recently, attention has given to the formation of stable charge-transfer complexes formed in the reaction of polynitrogen cyclic bases with iodine as a -acceptor and other -acceptors [1-3]. Reactions of electron donor 1,4,7,10,13,16-hexamethyl-1,4,7,10,13,16-hexaazacyclodecane (HMHCY) in the defined solvent at room temperature with excess of different electron acceptors such as iodine, 2,3-dichloro-5,6-dicyano-1,4-benzo-quinone (DDQ), picric acid (PA) chloranilic acid (CA), and 7,7´,8,8´-tetracyanoquinodimethane (TCNQ), tetracyanoethylene (TCNE), p-chloranil (Chl), respectively, resulted in formation of CT-complexes with a donor-acceptor ratio 1:4; ([(HMHCY)I]I7 (1), [(HMHCY)(DDQ)4] (2), [(HMHCY)(PA)4] (3), [(HMHCY)(CA)4] (4) and [(HMHCY)(TCNQ)4] (5), [(HMHCY)(TCNE)4] (6), [(HMHCY)(Chl)4] (7), respectively. Based on elemental analysis, IR and 1H NMR spectra of the CT-complexes along with the photometric titration curves for the reactions, the data obtained indicated the formation of 1:4 charge transfer complexes with a general formula [(HMHCY)(acceptor)4]. The aim of this research is to investigate the nature of the reaction between the polynitrogen cyclic base with these acceptors and the effect of the existence of the six electron donating methyl groups linked to the six nitrogen donors present in the cyclic base, HMHCY on the nature of the formed new CT-complexes.
[1] F Gutmann; C Johnson; H Keyzer; J. Molnár. Charge-Transfer Complexes in Biochemical Systems. Marcel Dekker Inc., (1997).
[2] E. M. Nour, A. S. Barakat, A. Amer, A. Ebrahim, Spectrosc. Lett., 32(1) (1999) 115.
[3] Akmal S. Gaballa, et al., Spectrochim. Acta A, 61(11-12), 2708-2712 (2005); J. Inorg. Chim. Acta, 357, 41444150 (2004); Indian J. Chem., 44A, 1372-1377 July (2005).

Ref : 373
Title : Numerical simulation of microstructure of ZnO varistors using surface energy calculation
Author(s) :
Name : Esraa Salah
Address : Faculty of Science, Menoufiya Univeristy
   
Accepted : 7/10/2016 6:03:00 AM    
Abstract :
The surface energies for zinc oxide (ZnO) surfaces doped with some metal oxides like Y2O3, MgO,V2O5, BaO, MnO2, MoO3,CuO, LiO2, Al2O3, SiO2, Bi2O3, Pr2O3 and Gd2O3 have been calculated by using a simulation modeling program. This was demonstrated by a direct comparison between the computed values and images which obtained from scanning electronic microscope (SEM) for many doping oxides. To this end, a simulation modeling via Matlab program has been built up. In which, draw factional image for ZnO microstructure doped with some oxides side by side with real images for these oxides with different doping ratio. Our findings indicate that this simulation modeling program will lead us directly in future to predict the morphology of the metal oxides, calculating its related parameters like the surface energy and displacing real SEM image with their equivalent simulated SEM.

Ref : 372
Title : Preparation and spectroscopic studies on charge-transfer complexes of 1,4,7,10,13,16-hexamethyl-1,4,7,10,13,16-hexaazacyclodecane with different acceptors
Author(s) :
Name : Akmal S. Gaballa
Address : Faculty of Specific Education, Zagazig University, Zagazig, Egypt
   
Name : S.M. Teleb
Address : bChemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
   
Name : S.M. Teleb
Address : bChemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
   
Name : E.M. Nour
Address : bChemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
   
Accepted : 7/9/2016 10:53:00 AM    
Abstract :
Reactions of electron donor 1,4,7,10,13,16-hexamethyl-1,4,7,10,13,16-hexaazacyclodecane (HMHCY) in the defined solvent at room temperature with excess of different electron acceptors such as iodine, 2,3-dichloro-5,6-dicyano-1,4-benzo-quinone (DDQ), picric acid (PA) chloranilic acid (CA), and 7,7´,8,8´-tetracyanoquinodimethane (TCNQ), respectively, resulted in formation of charge-transfer complexes with a donor-acceptor ratio 1:4; ([(HMHCY)I]I7 (1), [(HMHCY)(DDQ)4] (2), [(HMHCY)(PA)4] (3), [(HMHCY)(CA)4] (4) and [(HMHCY)(TCNQ)4] (5), respectively. These complexes are in general stable on air except the brown complex ([(HMHCY)I]I7 (1) was unstable in solution so, we were not able to isolate solid substance for microanalysis. For the sake of completion a similar reaction using KI/I2 has been carried out to isolate the corresponding solid potassium complex [K(HMHCY)]I7, 1a. Based on elemental analysis and IR spectra of the solid CT-complexes along with the photometric titration curves for the reactions, the data obtained indicated the formation of 1:4 charge transfer complexes [(HMHCY)(acceptor)4].


Ref : 371
Title : Comparative study of terbinafine hydrochloride transfersomes, menthosome and ethosome nanosize formulations via skin permeation and antifungal efficacy
Author(s) :
Name : Alaa A. Zaky
Address : Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
   
Name : Mahmoud M. Tawfick
Address : Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
   
Accepted : 7/9/2016 10:40:00 AM    
Abstract :
The purpose of the present research was to compare the skin permeation and study the antifungal efficacy of Terbinafine hydrochloride (TH) transfersomes, menthosome and ethosome formulations under non-occlusive conditions. Terbinafine hydrochloride (TH) is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Preparation of terbinafine hydrochloride transfersome utilized the mixture component model to determine the optimized desirable formula via using different concentrations of two nonionic surfactant span and tween (X1 & X2 respectively) were investigated. The results revealed that both X1 and X2 had a pronounced effect on vesicle size (Y1), zeta potential (Y2) and entrapment efficiency (EE) of the drug (Y3). The vesicles were prepared and characterized for shape, size, zeta-potential and entrapment efficiency. In vitro ex vivo study via Franz diffusion cells was used for the percutaneous absorption studies. The optimum desirable formula of transfersomes, menthosome and ethosome formulations were showed vesicle size (78.75, 122.8 and 97.80 nm) zeta potential (-8.28, 8.77 and 11.3mV) and encapsulation efficient of (92.67, 93.86 and 95.75%), respectively. In vitro permeation of the drug-loaded showed more than five-fold higher permeation rate compared with drug suspension. Deformability verified elasticity of the preparation. Finally, TH ethosome improved drug delivery with greater improvement in skin permeation and antifungal activity.

Ref : 370
Title : synthesis, molecular modeling and biological evaluation of pyridazine based scafolds as cancer targeting agents
Author(s) :
Name : Maiy Youssef Mohamed Jaballah
Address : College of Pharmacy, Ain shams university, Cairo, Egypt
   
Name : Khaled Abo-zeid Mohamed
Address : College of Pharmacy, Ain shams university, Cairo, Egypt
   
Name : Rabah Taha
Address : College of Pharmacy, Ain shams university, Cairo, Egypt
   
Name : Nasser saad
Address : College of Pharmacy, Ain shams university, Cairo, Egypt
   
Accepted : 7/8/2016 5:44:00 PM    
Abstract :
Cancer represents an enormous health burden, as it takes the third place in the most lethal death world wide.
understanding the pathophysiological causes of cancer can provide an effective therapeutic strategy to overcome such a disease. one of the hallmarks of cancer is Angiogenesis; i.e. the growth of new blood cells.
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in cancer angiogenesis. Through targeting VEGFR-2, angiogenesis is profoundly inhibited, leading to cancer regression.
In this study, pyridazine derivatives were designed, synthesized and biological evaluation as novel targeted antiangiogenesis inhibitors.
The design focused on exploration of the previous revealed SAR studies, bioisosteric modifications of the lead compounds both in market and in clinical studies, and identification of the key interactions with the binding site in silico.
Synthesis of the designed compounds was then accomplished & their structures were confirmed by various spectral and microanalytical data.
Biological evaluation comprised both enzymatic inhibition activity as well as in-vitro anticancer activity. Fourteen of the final Compounds were selected by the National Cancer Institute “NCI” for single dose screening program at 10 μM in the full NCI 60 cell panel. Some compounds showed excellent percentage inhibition activity against VEGFR, as well as IC50 that lies in the nanomolar range. Moreover, XXVIIIb showed the strongest inhibition of VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) with 99.98% inhibition at 10 μM concentration.
Finally, the designed and synthesized pyridazine derivatives showed to be a novel, promising anticancer candidates.

Ref : 369
Title : Isolation of starch from seven pearl millet grain landraces by two methods: wet milling and Ultrasound application.
Author(s) :
Name : Bouhallel Sarra
Address : Parc Mirement, Bouzareah, Immeuble Printania C, Algiers, Algeria.
   
Name : Badreddine Belhadi
Address : Algiers, Algeria
   
Name : Rachid Souilah
Address : Algiers, Algeria
   
Name : Djaafar Djabali
Address : Algiers, Algeria
   
Name : Boubekeur Nadjemi
Address : Algiers, Algeria
   
Accepted : 7/8/2016 6:04:00 PM    
Abstract :
The millets are the sixth most important cereal world-wide, they have a very good nutritional composition and can resist to difficult environment conditions (very low rainfall and saline soils). Because of the few and expensive starch sources, pearl millet could resurge as an easily available substitue . The objective of the present work was to add value to seven pearl millet (Pennisetum glaucum (L.) R. Br) landraces from south Algeria with high morphological variation through isolation of grain starch, and to enhance the yield by means of ultrasound treatment. The effects of pearl millet grain quality and starch isolation method on some properties of the starch isolates were evaluated. Two distinct methods were used; the wet milling method adding sodium azide as a microbial growth inhibitor at temperature 8 °C during 24h, and the ultrasound assisted isolation method at temperature of 40 °C, during 60 min, and with ultrasound treatment amplitude of 75 %. Isolated starches were characterized in terms of yield, recovery, chemical composition, and some physical properties to evaluate the efficiency of the isolation method. The ultrasound assisted isolation method gave better yields, better recoveries, and better starch purity, with ranges of (30.63 - 52.65 %), (46 - 75.70 %), and (91.32 - 94.58 %) respectively, it showed a great potential for pearl millet starch isolation in a short period of time without generating any alkaline effluent. Pearl millet grains resulted in acceptable starch yields, which could be useful especially in this country, where pearl millet could resurge as an important cereal crop. These studies are expected to be useful in the production of starch from highly nutritious, low cost and underutilized pearl millet grains.

Ref : 368
Title : The variability among Pearl Millet (Pennisetum glaucum (L.) R. Br) landraces grain from Algerian Sahara: Phenotypic traits and chemical composition
Author(s) :
Name : Bouhallel Sarra
Address : Parc Mirement, Bouzareah, Immeuble Printania C, Algiers, Algeria.
   
Name : Badreddine Belhadi
Address : Algiers, Algeria.
   
Name : Rachid Souilah
Address : Algiers, Algeria
   
Name : Djaafar Djabali
Address : Algiers, Algeria
   
Name : Boubekeur Nadjemi
Address : Algiers, Algeria
   
Accepted : 7/8/2016 6:03:00 PM    
Abstract :
The millets are the sixth most important cereal world-wide, they have a very good nutritional composition and can resist to difficult environment conditions (very low rainfall and saline soils). The main purpose of this study was to estimate the level of morphological and chemical composition variability, among 20 pearl millet landraces, for a best understanding of the correlations among pearl millet grain quality factors. Grains from twenty Pearl Millet (Pennisetum glaucum (L.) R. Br) landraces were collected from two areas of Algerian Sahara from 2005 to 2012 and analyzed for quantitative and qualitative traits and chemical composition. The one-way analysis of variance (ANOVA) showed that there are no significant differences between those areas. The studied grains showed a very important nutritional value with contents of starch and protein reaching 71.35% and 16.88% respectively. Considerable range of variation was recorded in grains volume, thousand grains weight, protein content, and the endosperm texture. The endosperm texture was farinaceous for most of grains. The chemical composition of the grain appears not to be significantly correlated to any of the other traits. The four principal components obtained which concern majorly the grain dimensions and endosperm texture, have explained (80.91 %) of the total variance. The present work showed that the phenotypic traits could classify the different pearl millet landraces mainly according to grain dimensions and endosperm texture, however variability in chemical composition was weak. A significant variation in phenotypic traits and a very important nutritional value in pearl millet grains from Algerian Sahara have been revealed.

Ref : 367
Title : Synthesis, Antiproliferative, and anti-tubulin Activity of Novel 1,2,4-Triazoles as potential combretastatin analogues.
Author(s) :
Name : Muhamad Mustafa
Address : Faculty of Pharmacy, Medicinal Chemistry Department, Minia University, Minia, Egypt
   
Name : ElShimaa Abdelhafez
Address : 5, Ramsis st, Ard sultan, Minia
   
Accepted : 7/8/2016 7:33:00 AM    
Abstract :
Combretastatin A4 (CA4) is a simple natural compound discovered three decades ago, its characterized by a very powerful inhibition of tubulin polymerization. However, CA4 was inactive in vivo because the cisoid configuration is transformed into trans.
In our work we designed and synthesized new cis restricted combretastatin analogues by introducing a heterocyclic five membered ring "1,2,4-triazle" instead of the carbon-carbon double bond.

Those synthesized compounds were tested for their cytotoxicity by the national cancer institute and exhibited significant cell growth inhibition against most tested cell lines. Moreover, in vitro tubulin polymerization inhibitory activity was evaluated on HepG2 cell lines. Docking studies showed several hydrophobic and hydrogen-bonding interactions with several amino acids with the colchicine binding site of β-subunit.


Ref : 365
Title : Formation of bis-xanthene derivatives under microwave irradiation and in conventional heating conditions
Author(s) :
Name : A.A.Abdelhamid
Address : Sohag University, Egypt
   
Name : N.G.Shikhaliyev, F.N.Naghiyev, A.N.Khalilov, A.G.Rahimova, S.A.Musayeva, A.T.Huseynova
Address : Baku State University, Azerbaijan
   
Accepted : 7/5/2016 11:18:00 AM    
Abstract :
Under microwave irradiation or conventional heating conditions by three component reaction of dimedone, appropriate aromatic aldehydes and amino alcohols in a stoichiometrical ratio (2:1:1) usually affords the formation of corresponding 3,6,6-tetramethyl-2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione derivatives in an excellent yield [1]. But when we used the pyridine-2,6-dicarboxaldehyde in standard reaction conditions the formation of desired bis-dihydroacridine-1,8-dione derivatives (1) did not occur. In this case the formation of unsymmetrical bis-xanthene-1,8-dione derivative took place [2]. The pyridine ring in the title compound (3) is connected to one tetramethyldecahydroxanthen-1,8-dionyl and one hydroxy-tetramethyloctahydro-xanthen-1,8-dionyl substituent in the 2- and 6-positions of the ring.
Interestingly, in this reactions when we replaced 1-amino-2-propanol to more sterically hindered tris(hydroxymethyl)aminomethane the formation of symmetrical 2,6-bis-tetramethyldecahydroxanthen-1,8-dione derivatives (2) occured. Obtained crystals were recrystallized in ethanol. The reaction was monitored by TLC, structure of synthesized compound has been confirmed by methods of IR, NMR spectroscopy and X-ray diffractometry.

References:

[1] A.A.Abdelhamid, S.K. Mohamed, A.M. Maharramov, A.N.Khalilov, M.A. Allahverdiev. Facile and efficient synthesis of acridinediones from primary amino alcohols via three-component condensation reactions assisted by microwave irradiation. Journal of Saudi Chemical Society, 2014, 18, 474–478.
[2] S.K.Mohamed, A.A.Abdelhamid, A.N.Khalilov, A.V.Gurbanov, S.W.Ng. 4a-Hydroxy-3,3,6,6-tetramethyl-9-[6-(3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,5,6,7,8,9-octahydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,4a,5,6,7,8,9,9a-decahydro-1H-xanthene-1,8-dione ethanol hemisolvate hemihydrate. Acta Cryst. (2011). E67, o850–o851

Ref : 364
Title : VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE MICRODETERMINATION OF GEMIFLOXACIN MESYLATE
Author(s) :
Name : Dina Salah El-Kafrawy
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt
   
Name : Mohamed el Sayed Mahrous
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt
   
Name : Saied Fathalla Belal
Address : Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt
   
Name : Salwa Thabat Hamad
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria 21521, Egypt
   
Accepted : 7/5/2016 10:49:00 AM    
Abstract :
In this work four different, simple, sensitive, accurate and precise spectrophotometric methods were developed for the determination of gemifloxacin mesylate in pure and in its pharmaceutical dosage form. The first and second methods depend on the reaction between gemifloxacin and ninhydrin reagent in methanol to form diketohydrindylidene-diketohydrindamine or Ruhemann`s purple. The first method [I] depends on the measurement of the formed purple color at 544nm, The second method [II] depends on measurement of the second derivative (D2) of the absorbance reading as peak to trough at 508-522 nm. The third method [III] depends on the reaction of the drug with 2,4-dinitrofluorobenzene (DNFB) reagent in an alkaline medium to yield a yellow colored product measured at 360 nm. In the fourth method [IV] chloranil is used as a color reagent that reacts with the drug to produce yellow colored product measured at 350 nm. Beer’s law was obeyed in the concentration ranges of 10-50 µg ml-1 for [I] and [II] , 3-15 µg ml-1 for [III] and 4-10 µg ml-1 for [IV]. The proposed methods were successfully applied to the assay of gemifloxacin mesylate in pure and tablet form with good accuracy and precision. Assay results were statistically compared to a published UV-VIS method (1) where no significant differences were observed between the proposed methods and reference method.

Ref : 363
Title : Theoretical and Experimental Study on the Effect of End Chain Length on Ultraviolet Absorption Behavior and Photo Stability of Alkoxy Benzoate Based Liquid Crystals
Author(s) :
Name : Ahmed M. El Defrawy
Address : Chemistry Department, Faculty of Applied Science, Umm Al Qura University, Sadui Arabia. Chemistry Department, Faculty of Science, Mansoura University, Egypt.
   
Name : Said Z. Mohammady
Address : Chemistry Department, Faculty of Applied Science, Umm Al Qura University, Sadui Arabia. Chemistry Department, Faculty of Science, Cairo University, Egypt
   
Name : Marwa G. El Ghalban
Address : Chemistry Department, Faculty of Applied Science, Umm Al Qura University, Sadui Arabia. Chemistry Department, Faculty of Science, Mansoura University, Egypt.
   
Name : Hossa F. El Sharief
Address : Chemistry Department, Faculty of Applied Science, Umm Al Qura University, Sadui Arabia
   
Accepted : 7/5/2016 8:08:00 AM    
Abstract :
Liquid crystals homologous of 4-(4-chlorobenzoyloxy)phenyl 4-(n-alkoxy)benzoate (nCBPAB: n=8,14,16, where n is the number of carbon atoms in the alkoxy chain) were prepared and investigated for their liquid crystalline properties. The geometrical parameters and atomic charge distribution of the nCBPAB structures under investigation have been calculated using DFT level of calculation applying the B3LYP/6-31G(d) basis set. TD-DFT calculations have been used to predict the absorption spectra of the considered molecules. Further, theoretically predicted molecular descriptors have been used to correlate with the phase stability of these molecules. In addition to that, the photo stability of these molecules has been investigated which provide valuable data for experimental applications.

Ref : 362
Title : The synthesis of Bi2(TeSe)3 nanoparticles for clean energy production: Effect of the synthesis conditions
Author(s) :
Name : M.A.A. Mohamed, E.M.M. Ibrahim, H.M. Ali, M.M. Wakkad
Address : Physics Department, Faculty of Science, Sohag University, Sohag-82524, Egypt
   
Accepted : 7/4/2016 5:06:00 PM    
Abstract :
Thermoelectric power generators are promising technique for clean energy production. They are used for transforming the waste energy to electricity in environment friendly ways without any noise or pollutants. In this work, Bi2(TeSe)3 nanoparticles (NPs) were successfully prepared via vapor transport technique. The x-ray diffraction (XRD) patterns show that, the NPs crystalize in a rhombohedral structure. Field-emission scanning electron microscope (FE-SEM) investigation reveals that the NPs size depends significantly on the synthesis conditions of flow rate and temperature where it decreases as one or both of them decreases. The photoluminescence spectra were utilized to describe the free carriers transfer between different energy states and hence they were helpful for understanding the electrical conduction mechanisms. The electrical and thermoelectrical properties were measured over a wide range of temperature 300-600 K. The calculated power factor confirms the effect of particle size on the thermoelectric properties of the Bi2(TeSe)3 compounds.

Ref : 361
Title : Magnetic Nanoparticles for Cancer Terapy: Facile Synthesis Techniques and Desired Properties
Author(s) :
Name : E.M.M. Ibrahim
Address : Physics Department, Faculty of Science, Sohag University, Sohag-82524, Egypt
   
Name : G. Farghal1, Mai M. Khalaf2, Hany M. Abd El-Lateef2, S. Hampel3, V. Khavrus3, C. Täschner3, A. Leonhardt3, B. Büchner3
Address : 1Physics Department, Faculty of Science, Sohag University, Sohag-82524, Egypt 2Chemistry Department, Faculty of Science, Sohag University, Sohag-82524, Egypt 3Leibniz Institute of Solid State and Material Research Dresden, D-01171 Dresden, Germany
   
Accepted : 7/4/2016 4:35:00 PM    
Abstract :
During last decade, magnetic nanoparticles (MNPs) have attracted an increasing interest for many aspects of applications such as biomedicine, chemical technology, magnetic data storage devices, and nanoscale electronics due to their unique chemical and physical properties. In fact, one of the tremendous areas of growth on the research side involves using MNPs for cancer treatment. MNPs with appropriate surface have been successfully applied to deliver therapeutic biomolecules, such as anticancer drugs, antibodies, and siRNA, to target tumour cells and tissues. Also, They can heat up in Ac magnetic fields, thus act as hyperthermia agents. On the other hand, in cancer diagnostic field, MNPs play an important role as MRI contrast enhancement agents.
The potential applicability of MNPs in cancer treatments varies widely depending on their magnetic properties and chemical stability. Actually, various factors can tune the magnetism of the MNPs. A main issue is the individual properties of the magnetic nanoparticles including chemical composition, size, and shape. To ensure the safe use in biomedicine, the chemical stability can be achieved by producing magnetic nanocomposites (MCs). In MCs, the MNPs are coated with shells of highly chemical stable materials such as carbon, silica or polymers. The fascinating properties revealed by the MCs are emerged due to the combination of the MNPs and the coating shells: the MCs acquire magnetic functionality such as monitoring, heating, and guiding from the MNPs, while the coating shells improve the chemical stability, chemical functionality, and biocompatibility.
This work presents our results of the synthesis of Mn0.5Zn0.5Fe2O4, BiFeO3 MNPs, and carbon coated Fe, Co, Ni, FeCo, FeNi MNPs. The magnetic properties, heating response in AC magnetic fields for hyperthermia applications and biocompatibility of the synthesized magnetic systems were studied. Various synthesis methods such as chemical precipitation, chemical vapour deposition, plasma enhanced chemical vapor deposition and ball milling were used and reported to show the crucial role of the synthesis technique for tuning the magnetic and chemical stability of the materials. Different rare earth elements were used for doping the magnetic nanoparticles to enhance their magnetic properties.
Keywords: magnetic nanoparticles; Plasma; Chemical vapour deposition, hyperthermia, drug delivery.

Ref : 360
Title : N-Tert-butyl-3-mesitylpropanamide – The synthesis and antimicrobial assessment
Author(s) :
Name : A.A.Abdelhamid
Address : Sohag University, Egypt
   
Name : A.M.Maharramov, V.A.Ismayilova, F.N.Naghiyev, Kh.A.Asadov, A.N.Khalilov, A.T.Huseynova
Address : Baku State University, Azerbaijan
   
Accepted : 7/4/2016 10:47:00 AM    
Abstract :
The amide moiety is a common feature in synthetic or natural molecules. Amide bonds play a major role in the elaboration and composition of biological systems and are very frequently incorporated into active pharmaceutical ingredients. Above mentioned findings suggested that some amides may be promising therapeutic agents. Herein, we report the synthetic approach to N-tert-butyl-3-mesitylpropanamide and its initial antimicrobial assessment. Obtained colorless crystals were recrystallized in ethanol. The proposed mechanism of this reaction runs through the Favorskii-type rearrangement.
The reaction was monitored by TLC, structure of synthesized compound has been confirmed by methods of IR, NMR spectroscopy and X-ray diffractometry. In this compound the N-tert-butylpropanamide fragment is essentially planar, with the exception of two C atoms of the tert-butyl group, forming a dihedral angle of 84.09 (10) with the plane of the mesityl fragment. The crystal packing is stabilized by an intermolecular N–H∙∙∙O hydrogen bond, which links the molecules into chains with graph-set notation C(4) running parallel to the c axis.
Antimicrobial assessment of this compound has been runned for its growth inhibitory activity against St. aureus, Ps. aeruginosa, E. coli and Cand. albicans by serial dilution method. The %1 solution of title compound in ethanol was diluted in ratios of 1:100, 1:200, 1:400, 1:800 using distilled water. To the all diluted samples was added one drop of microbial emulsion, which 1 cc of such emulsion contain about 500 million microbes. Then, all infected samples passed through growth control in nutrient medium in every 10-20 minutes during one hour. As a nutrient medium have been used the meat peptone for bacterial cultivations, incubated at 37C for 24 hour and Sabouraud agar for fungal cultivations, incubated at 28C for 48 hour in thermostat. The antimicrobial activity has been tested in comparison with the blank sample (EtOH) and with the known antiseptics (ethanol,nitrofural, chlornitrophenol). This time-kill test revealed a time-dependent and a concentration dependent antimicrobial effect of this compound. The results showed the title compound has demonstrated the promising antimicrobial activity.

Ref : 359
Title : Equilbrium, Anticancer and Antimicrobial Studies of Pd(2-(ethylthio)ethylamine)Cl2] Nano-Complex Involving DNA Constituents
Author(s) :
Name : Mohamed Refaat Shehata
Address : Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
   
Name : Mervat S. Mostafa
Address : Science and Technology Center of Excellence (STCE), Ministry of Military Production, Cairo, Egypt
   
Accepted : 7/4/2016 7:52:00 AM    
Abstract :
Novel solid Nano-Pd (II) complex was synthesized of different sizes. The structure of complex was proposed in light of potentiometric, TGA, IR, 1H-NMR and UV/Vis spectral data. DFT method was used to obtain 3D modelling of the ligand and its metal complex with Gaussian 09 program at the B3LYP//LANL2DZ level of theory. The acid-base properties of [Pd(ETEA)(H2O)2]2+, where ETEA = 2-(ethylthio)ethylamine were studied at 25 ºC and 0.1 M ionic strength. The stoichiometry and stability constants of the complexes formed between [Pd(ETEA)(H2O)2]2+ and DNA constituents were studied at 25 ºC and 0.1 M ionic strength and the results show the formation of Pd:DNA complexes of 1:1 and 1:2 ratios. The potentiometric results were confirmed by spectroscopic measurements. Palladium nano-complexes were synthesized and characterized by High Resolution Transmission Electron Microscopy (HRTEM) and Dynamic Light Scattering (DLS). HRTEM showed that their particles are in nano-scale with a diameter of ~3.5 and 87 nm. Nano metal complex of different sizes were tested and compared for antimicrobial activities and antitumor against the human breast cancer cell line (MCF-7).

Ref : 358
Title : Used Engine oils refining using different types of solvent Mixtures
Author(s) :
Name : Doaa I. Osman, Sayed K. Attia and Afaf R. Tama
Address : Egyptian Petroleum Research Institute
   
Accepted : 7/3/2016 9:58:00 PM    
Abstract :
The significant quantities of used and discharged lubricating oil pose a major environmental problem around the world. Recently, this has been a growing interest in the sustainable usage of lubricating oils by a doubling recovery, recycle and reuse strategies. In this study the recovery of base oils from used lubricants was investigated using a novel combination of solvent extraction and activated alumina adsorbent. The performance of these extracting solvent mixtures {toluene +butanol and methanol (A)}, {toluene + butanole and ethanol (B)} and {toluene +butanol +iso propanol (C)} was evaluated experimentally, solvent to oil ratios from 1:1 to 1:3 were examined for solvent mixture (C). The results show solvent mixture (A) the best performance with the maximum percent sludge removal. The percentage of sludge removal increase with the increase of solvent to oil ratios. The application of an activated alumina process was investigated. The physical properties of the treated oil were measured. The results show the improvement in the properties of treated oil and have the best performance.

Ref : 357
Title : EFFECTIVE GENERAL SCIENCE TEACHING METHODS
Author(s) :
Name : DR. RAJA MOHAMMAD LATIF
Address : Department of Mathematics and Natural Sciences Prince Mohammad Bin Fahd University P.O. Box 1664 Al Khobar 31952 Kingdom of Saudi Arabia
   
Accepted : 7/3/2016 3:20:00 PM    
Abstract :
Our every day is different from the earlier days and this is largely due to the contribution of science in our life. We can’t live happy life without Science. The science has become integral part of our life. Science has also influenced educational enterprise and hence it is also the integral part of our educational system. Learning of science has become unavoidable part of general education. The modern civilization is a scientific civilization. In this age the modern society is completely drawn into the scientific environment. Today science has become an integral part of our life and living. Now we cannot think of a world without science. I think teaching is an art and there are born teachers. But there are majority of teachers, who can improve upon by experience of practice and utilization of various methods of teaching science. The basic aim of teaching any subject is to bring about desired change in behavior. The change in behavior of child will be indicated through children’s capacity to learn effectively. This is only possible by adopting various methods of teaching. The teacher cannot utilize any method to any type of students in any type of environment. One has to choose and adopt the right method of teaching keeping in mind the capability of the students and the curriculum. Thus, method in a way of presentation of the content in the classroom. But, it is however very important to keep in mind that a method is not an end in itself but is used to achieve the set aims of teaching. You should also keep in mind that, same method should not be used at all times but there should be flexibility in using it as for as situations circumstances, and condition in a particular case. You should use various methods depending upon demand of the situation. The method which in a particular class under a particular circumstance, may be a total failure for other teacher. The best methods of teaching science are Teacher-Centered and Pupil-Centered. The first type of teaching methods focus on telling, memorizing, recalling information. The students participation is very limited where in they only ask questions or answer questions. Most of the time the students are passive listeners and receive the knowledge. The teacher is center of process that goes on in the classroom. The second type of teaching process emphasizes on need, requirement, interest and capability of students. The students are active participants where in their skills and abilities are developed. Teacher and students jointly explore the different aspects of problem. The role of the teacher is to create a problematic situation, have materials and resources available to the students, and help them identify issues, state hypotheses, clarify and test hypotheses and draw conclusions. If you are keen in making lesson plans which may help you in achieving your identified objectives, then they should be stated clearly. If objectives are not clearly defined, it is impossible to evaluate a student, a lesson, a unit, a course or a program effectively. This leads to teaching disaster. Unless you have clear picture of instructional intention, you will be unable to select test items in which the objectives are clearly defined and the students know which activities are relevant for success of the teaching learning process. A meaningfully stated objective is that clearly communicate the readers the writer’s intention- It states the behavioral outcome students after completing a certain topic. The most important characteristics of useful objectives are that it identifies the kind of performance that will be accepted as evidence that the learner has achieved the objective. In this talk we shall discuss the meaning importance and place of science in educational institution curriculum and general and specific instructional objectives. We shall also learn about organization of science curriculum using disciplinary approach and integrated approach. We develop an understanding of different methods of teaching science. The developments include an understanding of lecture-cum-discussion method, laboratory method and its utilization in teaching of science, importance of observation method in science teaching, project method and problem solving method. We will elaborate principles, merit and limitations of lecture – cum – discussion method. We will be stating important role of a teacher and provide suggestions for effective science teaching methods.

Ref : 356
Title : Kinetic, Thermodynamic and Adsorption Studies of the uptake of Methylene Blue Dye by CuO nanoparticles pre adsorbed Congo Red dye.
Author(s) :
Name : Mohamed H. Elsayed
Address : Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
   
Name : Taha M. Elmorsi
Address : Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
   
Accepted : 7/3/2016 11:52:00 AM    
Abstract :
This research aims to enhance the adsorption of methylene blue (MB) dye onto the surface of CuO nanoparticles pre adsorbed by congo red (CR) dye which namely CuO/CR. Pre adsorption process was used to produce Lewis acid on the surface of CuO to attract any Lewis base such as MB. In addition, CuO/CR has the ability to resist the change in pH values from 3 to 9 which increases its stability in acidic and alkaline media. As produced CuO/CR was characterized by scanning electron microscopy, X-ray diffraction and FT-IR. The effects of several parameters on the adsorption process were studied. Three different kinetic equations, pseudo-first order, pseudo-second order and Elovich equations along with intraparticle diffusion were used to study the order and the mechanism of the adsorption process. Based on the value of R2, the adsorption of MB dye followed pseudo-second order equation. CuO/CR increased the adsorption capacity of MB by 5 times more than pure CuO. In addition, the data were fitted well with Langmuir with maximum capacity of 49.5 mg/g. Thermodynamic parameters ΔGº, ΔHº and ΔSº were determined at different temperature (10 to 30 °C).

Ref : 355
Title : Novel Synthesis of Polymer Based Nanocomposites As Smart Energy Storage Media.
Author(s) :
Name : Nour F. Attia
Address : Fire Protection Laboratory, Chemistry Division, National Institute for Standards, 136, Giza 12211, Egypt
   
Name : Kamal Abdel hady
Address : Physics Department, Faculty of Science, Mina University, Mina, Egypt.
   
Name : Amany Abdel- Hady
Address : Physics Department, Faculty of Science, Mina University, Mina, Egypt.
   
Name : M. A. Refaat
Address : Physics Department, Faculty of Science, Mina University, Mina, Egypt.
   
Accepted : 7/2/2016 11:12:00 AM    
Abstract :
The rapid growth of the world population, in conjunction with industry expansion in many developing countries attributed to increasing the fossil fuels consumption and their pollution problems. This also attributed to the prediction of energy and environmental pollution crises [1]. However, the solution of energy crisis will be the main step for solving other crises. This encourages scientists to find another potential clean and renewable source of energy for replacement of fossil fuels and to meet the world needs [2, 3]. So that, the production and storage of renewable energy is the main challenge and task. In this study, smart polymer based nanocomposite were developed for supercapacitors applications. The developed nanocomposite materials were optimized and tuned through preparation method and variation of mass ratio of components. The morphology and structure properties of the developed nanocomposites were characterized using microscopic and spectroscopic techniques. References
1. N. F. Attia, K. E. Geckeler, Macromol. Rapid Commun. 2013, 34, 1043.
2. N. F. Attia, M. M. Menemparabath , S. Arepalli, K. E. Geckeler KE, Int. J. Hydrogen Energy 2013,38, 9251. 3. N. F. Attia, S. M. Lee, H. J. Kim , K. E. Geckeler, Int. J. Energy Res. 2014,38,466.

Ref : 354
Title : A new Study On Phosphodiesterase Type 5 Inhibitors : Beyond Their Current Action On Erectile Dysfunction
Author(s) :
Name : yaseen A. M. Mohamed Elshaier
Address : Pharmaceuitical Organic Chemistry Dep., Faculty of Pharmacy, Al-Azhar university, Assuit, Egypt
   
Name : Mohamed R. A. Marzouk
Address : Faculty of Pharmacy, Al-Azhar university, Assuit, Egypt
   
Name : Mahmoud I. G. Ismail
Address : Faculty of Pharmacy, Al-Azhar university, Assuit, Egypt
   
Accepted : 7/2/2016 8:07:00 AM    
Abstract :
Phosphodiesterase type 5 (PDE-5) inhibitors are the drug of choice for treatment erectile dysfunction (ED). The great evolve in PDE 5 inhibitors from first generation as slidenafil to third generation as avanafile turns the attention of physicians and medicinal chemists to enlarge their application in different human disease and overcome their current drawbacks. This study explores PDE-5 inhibitors have other applications in treatment of different disease as in colon cancer, Prostatic enlargement and Eisenmenger’s Syndrome. In this regard, we designed and synthesize a new serious of pyrazolo[3,4-d] pyramids ones as slidenafil analogies. The docking study was generated by using OpenEye program and using IOXP as PDE-5 coded proteins for generation of docking study. The best compounds will undergo anti cancer evaluation and for further docking studies.

Ref : 353
Title : Comparative study of terbinafine hydrochloride transfersomes, menthosome and ethosome nanosize formulations via skin permeation and antifungal efficacy
Author(s) :
Name : Alaa A. Zaky
Address : Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
   
Accepted : 7/2/2016 8:08:00 AM    
Abstract :
The purpose of the present research was to compare the skin permeation and study the antifungal efficacy of Terbinafine hydrochloride (TH) transfersomes, menthosome and ethosome formulations under non-occlusive conditions. Terbinafine hydrochloride (TH) is an antifungal drug for onychomycosis. Poor permeability of its external preparation leads to poor curative effect. Preparation of terbinafine hydrochloride transfersome utilized the mixture component model to determine the optimized desirable formula via using different concentrations of two nonionic surfactant span and tween (X1 & X2 respectively) were investigated. The results revealed that both X1 and X2 had a pronounced effect on vesicle size (Y1), zeta potential (Y2) and entrapment efficiency (EE) of the drug (Y3). The vesicles were prepared and characterized for shape, size, zeta-potential and entrapment efficiency. In vitro ex vivo study via Franz diffusion cells was used for the percutaneous absorption studies. The optimum desirable formula of transfersomes, menthosome and ethosome formulations were showed vesicle size (78.75, 122.8 and 97.80 nm) zeta potential (-8.28, 8.77 and 11.3mV) and encapsulation efficient of (92.67, 93.86 and 95.75%), respectively. In vitro permeation of the drug-loaded showed more than five-fold higher permeation rate compared with drug suspension. Deformability verified elasticity of the preparation. Finally, TH ethosome improved drug delivery with greater improvement in skin permeation and antifungal activity.

Ref : 352
Title : Asymmetric one pot synthesis of novel pyridazino[1,6]napthyridines and evaluation of their antibacterial activity
Author(s) :
Name : Noha M. H. Elnagdi
Address : Faculty of pharmacy, Modern University for Technology and Information, Mokattam, Cairo
   
Name : Nader Afify
Address : Faculty of pharmacy, Modern University for Technology and Information, Mokattam, Cairo
   
Accepted : 7/2/2016 5:22:00 AM    
Abstract :
A series of Pyridazino[5,4,3-de][1,6]naphthyridines were stereoselectively synthesized in one pot via reacting aryl hydrazono esters with 3-aminoprop-1-ene-1,1,2-tricarbonitrile and ketones in presence of chiral catalysts under mild reaction condi-tions. The enantiomeric excesses could be determined from relative heights of diastereotopic protons in reaction products using 1H NMR spectroscopy. Evaluation of Pyridazino[5,4,3-de][1,6]naphthyridines as antimicrobial agents is also reported.

Ref : 351
Title : Novel Indolyl-Isoindole Derivatives: Design, Synthesis, and In-vitro Evaluation against different Cancer Cell Lines
Author(s) :
Name : Magdy A.H. Zahran
Address : Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt
   
Name : Bishoy Y. El-Aarag
Address : Chemistry Department, Biochemistry Specialty, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt
   
Name : Ali S. Younes
Address : Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt
   
Accepted : 7/1/2016 5:43:00 PM    
Abstract :
A series of novel indolyl-isoindole derivatives containing indole and brominated indole moieties (derivatives 4–10) were synthesized through alkylation of compound (A) followed by bromination. In-vitro anti-tumor evaluation of these novel derivatives was carried out on different human cancer cell lines such as (Hep-G2) liver cancer, (CACO-2) colon cancer, (MCF-7) breast cancer, and (A549 & H1299) lung cancer. Results revealed that, all derivatives exhibited cytotoxic selectivity against Hep-G2, especially derivative (4) which showed a moderate cytotoxic effect compared with drug thalidomide (IC50 = 23 & 50 µM). Furthermore, derivative (7) showed a slight cytotoxicity against CACO-2 cell line compared with thalidomide (IC50 = 20.4 & 22.9 µM, respectively). Moreover, all derivatives showed resistance effect against A549, H1299, and MCF-7 cell lines compared with thalidomide.

Ref : 350
Title : Room temperature Na2CO3-catalysed one-pot reaction of benzaldehydes, malononitrile and phloroglucinol in water, a simple green synthetic route to 2-amino-4H-chromenes
Author(s) :
Name : Shetonde O. Mihigo
Address : Department of chemistry, University of Kinshasa, P. O. Box 190, Kinshasa XI, DR Congo.
   
Name : shmael B Masesane
Address : Department of Chemistry, University of Botswana, Private Bag 00704, Gaborone, Botswana.
   
Accepted : 7/1/2016 10:38:00 AM    
Abstract :
One important aspect of Green Chemistry is the elimination of organic solvents in chemical processes or the replacement of hazardous solvents with relatively benign ones. Water, being the most environmental benign, cheapest, non flammable and naturally occurring solvent, is the first choice. In addition, the synthesis of bioactive compounds within a reduced number of chemical steps, reaction time, cost, man power, and under mild conditions is highly desirable. Thus, one important development that marks recent years are multicomponent reactions (MCRs) which are one-pot processes in which three or more components are combined together to produce a final product that features contributions from all the input reactants.
On the other hand, chromene (Benzopyran) derivatives represent a significant class of oxygen-containing heterocycles whose high biological activity provides broad prospects for their practical applications. They draw a special attention due to their proven pharmaceutical properties that include the antifungal, herbicidal, antitumor, antihepatotoxic, antioxidant, anti-inflammatory, diuretic, anticoagulant, antispasmolytic, estrogenic, antiviral, antimicrobial, anti-helminthic, hypothermal, vasodilatory, anti-HIV, antitubercular, anticonvulsant and analgesic activities.
Despite the existence of several effective methods for the synthesis of 2-Amino-4H-chromenes, the development of an inexpensive, mild, general, and energy efficient green procedure remains an issue of interest. In this regard and as part of our continued interest in the synthesis of heterocyclic compounds and green chemistry, we decided to explore the green synthesis of a series of 2-Amino-4H-chromene analogues with varied functional groups at the 4-position of the chromene system. Our main methodology has been a simple one-pot three component reaction of benzaldehydes, malononitrile and phloroglucinol in water to give 4-phenyl-2-amino-4H-chromenes, using catalytic Na2CO3. Our interest in the use of Na2CO3 in synthesis is because it is produced in large quantities in Sua, Republic of Botswana, and has extensive domestic use, therefore relatively safe. Thus, the three reagents were dissolved in minimum amount of MeOH and to this was added a solution of Na2CO3 in water/ MeOH (95:5, v/v). The resulting suspension was then vigorously stirred at room temperature for 8-10 hours to give the targeted 2-Amino-4H-chromenes as whitish or pale-yellow solids.
Over 17 compounds have been successfully synthesized (Yields: 65-96%) and characterized. The characteristic signals for 4H-chromenes resonating at between δ 4.43-4.95 for 1H NMR and δ 32.3-36.9 for 13C NMR were particularly useful in ascertaining the structure of the synthesized compounds. Details of our approach will be presented and discussed.
Keywords: Green chemistry, 2-Amino-4H-chromenes, Multicomponent reaction, Water.

Ref : 349
Title : Interstellar Space Chemistry: An Overview
Author(s) :
Name : Osama M. SHALABIEA
Address : Faculty of Science, Cairo University, Giza, Egypt
   
Accepted : 7/1/2016 7:22:00 AM    
Abstract :
It is a remarkable fact that the last 25 years have revolutionized our view of the importance of chemistry in the universe. Our view of both physics and chemistry of interstellar dust and gas-phase composition too, have changed very significantly and we expected even more in the next century, when new observational facilities become available. Although extensive research has been done, an enormous amount of research is still needed before our understanding of interstellar space chemistry is at all complete. In this work, we will review the new trends of chemistry in interstellar space, from historical back ground through recent success to end up with the current challenges.


Ref : 347
Title : Effect of Cu2+ Concentration on Adsorption - Sorption Mechanisms, Modes, Critical Concentration Edge, and Spontaneity of Square Cu2+ ammonia complex ion [Cu (NH3)4]2+ on γ Alumina
Author(s) :
Name : Adel R. Ismaeel
Address : Benghazi University, Faculty of science, Chemistry Department, Benghazi, Libya.
   
Name : Khaled M. Edbye
Address : Benghazi University, Faculty of science, Chemistry Department, Benghazi, Libya.
   
Accepted : 6/30/2016 6:38:00 PM    
Abstract :
ABSTRACT
Aims: To apply a fast, & save method for water treatments by using physical removal of toxic metal ions such as Cu2+ by adsorption at solid insoluble, non toxic, reusable adsorbent as γ Alumina. to indicate the effects of Cu2+ concentrations ranges on the adsorption modes, mechanisms, maximum efficiency, and the thermodynamic parameters indicating spontaneity of the processes. As we have to get strong adsorption to avoid desorption of ions to solution but the low apparent adsorption spontaneity was contradicted (not inconsistent) with the produced high strength of adsorption) encourage us to determined the true free energy change for each adsorption mode by studying the adsorption mechanism, and energy relations of each adsorption mode. Place and Duration of Study: The Experimental part of research was done in Benghazi University, Chemistry Department, Benghazi Libya between May to Sept. 1011.
Methodology: Solutions of concentrations from, 1.5 to 15.5 x10-3M of Cu2+ which resembling that of industrial, agriculture, and waste water. Cu2+ form cupric ammonia square complex ion, (CASCI) [Cu(NH3)4] 2+ was prepared by dissolving in buffer solution to be maintained at p H = 11. The batch technique of adsorption test was followed in testing 50 ml of each test solution which was simultaneously shacked with 0.5 gram adsorbent ( γ Al2O3 ) for 60 minutes with shacking rate of 300 cycle per minute using water thermostat shaker at 30ºC. The amount of Cu2+ adsorbed was determined by measuring the difference of its concentration before, and after adsorption by measuring the optical density of the blue
[Cu (NH3)4)]2+ solutions ,using spectroscopic method with a beam of wave length 580nm.
Results: The results were applicable to Langmuir, and Ismaeel adsorption isotherms all over this concentration range but it show a deflection of Langmuir line, and deflection with splitting of Ismaeel line at the same equilibrium concentration edge (CE) which divided the isotherms into two low, and higher concentrations ranges. The same divisions were occurred also to the lines of the relations of the solution concentration versus adsorption rate, the surface coverage fraction θ, the adsorption efficiency %, and spontaneity indicating two modes, and mechanisms of adsorption before and after CE.
Conclusion: We have to avoid applying adsorption processes on concentrations higher than the CE, by using dilution with pure water to just lower the concentration than CE or, by increasing the mass of adsorbent. gain maximum (adsorption- sorption), Spontaneity, Efficiency, Rate, and Surface coverage % Applying Ismaeel adsorption isotherm, enable to know the adsorption modes, and activation energy used to release and replace the water molecules already adsorbed on adsorbent surface, and determining the true value of adsorption free energy change which identify the adsorption type as, chemisorptions confirmed by the high adsorption spontaneity as ∆G true reached more negative than -300 KJM-1.
Keywords: Isotherm; sorption; γ Alumina; (XAFS); concentration edge

Ref : 346
Title : Geometrical engineering of magnetization reversal in Ni, Co and NiFe- based antidot lattices
Author(s) :
Name : M. Salaheldeen
Address : 1) Physics Department, Faculty of Science, Sohag University, 82524 Sohag, Egypt 2) Depto. Física, Universidad de Oviedo, CalvoSotelo s/n, 33007 Oviedo, Asturias, Spain
   
Name : M.Raaif
Address : Physics Department, Faculty of Science, Sohag University, 82524 Sohag, Egypt
   
Name : J.M. Teixeira, V.M. Prida
Address : Depto. Física, Universidad de Oviedo, CalvoSotelo s/n, 33007 Oviedo, Asturias, Spain
   
Name : A. Fernández
Address : Depto. Física, Universidad de Oviedo, CalvoSotelo s/n, 33007 Oviedo, Asturias, Spain
   
Accepted : 6/30/2016 11:21:00 AM    
Abstract :
Antidot lattices can be used to artificially engineer themagnetic properties of thin films, however, a conclusive model that describes the coercivity enhancement in this typeof magnetic nano-structures has so far not been found. Ni, Co and NiFe-basedantidots thin films were grown by high vacuum thermal electron beam evaporation of a high purity Ni, Co and Permalloy layer, respectivelydeposited on the top surface of a nanoporous alumina membrane employed as patterned template, while the continuous films were deposited on a flat electropolishedaluminium substrate. Geometrical characteristics as nanoholes diameter, holes inter-distance and the overall hexagonal symmetry of the antidot arrays are controlled through the original pores size and their arrangement from the starting alumina templates [1]. We prepared Ni, Co and NiFe thin films and patterned with layer thickness of 30 nm for NiFe and 50 nm for Ni & Co, each with circular antidot lattices with varying their geometric parameters. The morphological structure was observed by scanning electron microscope (SEM), the surfacemagnetic properties were investigatedby magneto-optic Kerr effect (MOKE) and the bulk ones by vibrating sample magnetometry (VSM) techniques. To get a deeper insight into the magnetization reversal processes of the antidot nanostructures, we have also performed micromagnetic simulations by Mumax3 package with finite element discretization.On the basis of this extensive dataset, we are able to provide a model that can describe both the coercivityHc and remanenceMr scaling over a wide range of geometric lattice parameters and the influence of different magnetic materials.
References

[1] F Beron, A. Kaidatzis, M.F. Velo, L.C.C. Arzuza, E.M. Palmero, R. P. del Real, D. Niarchos, K.R. Pirota, J.M. García-Martín, Nanoscale Res. Lett. 11 (2016) 86.

Acknowledgements
Financial support under Spanish MINECO research Project No. MAT2013-48054-C2-2-R and Principality of Asturias from FICyT project No. FC-15-GRUPIN14-085.

Ref : 345
Title : Validated Stability-Indicating HPLC-DAD Method for Determination of the Recently Approved Hepatitis C Antiviral Agent Daclatasvir
Author(s) :
Name : Mostafa M. Baker
Address : Methodology Department, Pharco Pharmaceuticals Company, Alexandria, Egypt
   
Name : Tarek S. Belal
Address : Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah 21521, Alexandria, Egypt
   
Name : Dina S. El-Kafrawy
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah 21521, Alexandria, Egypt
   
Name : Mohamed S. Mahrous
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah 21521, Alexandria, Egypt
   
Accepted : 6/30/2016 11:17:00 AM    
Abstract :
A comprehensive stability indicating HPLC with diode array detection method was developed for determination of the recently approved antiviral drug daclatasvir dihydrochloride (DCV) which is used for the treatment of chronic Hepatitis C Virus (HCV) genotype 3 infection. Effective chromatographic separation was achieved using Waters C8 column (4.6 × 250 mm, 5 µm particle size) with isocratic elution of the mobile phase composed of mixed phosphate buffer pH 2.5 and acetonitrile in the ratio of 75:25 (by volume). The mobile phase was pumped at a flow rate of 1.2 mL/min, and quantification of DCV was based on measuring its peak areas at 306 nm. DCV eluted at retention time 5.4 min. Analytical performance of the proposed HPLC procedure was thoroughly validated with respect to system suitability, linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. The linearity range was 0.6 – 60 µg/mL with correlation coefficient >0.99999. The drug was subjected to forced degradation conditions of neutral, acidic and alkaline hydrolysis, oxidation and thermal degradation. The proposed method proved to be stability-indicating by resolution of the drug from its forced degradation products. The validated HPLC method was successfully applied to analysis of the cited drug in its tablets.

Ref : 344
Title : Formulation and optimization of vardenafil hydrochloride oral disintegrating tablets: effect of superdisintegrants
Author(s) :
Name : Hossameldin Mohamed Kadry
Address : Pharmaceutics department, Faculty of Pharmacy, Al-Azhar University, Cairo
   
Name : Alaa Abdallah Zaky
Address : Pharmaceutics department, Faculty of Pharmacy, Al-Azhar University, Cairo
   
Name : Alaa Eldin Ali ALi Kassem
Address : Pharmaceutics department, Faculty of Pharmacy, Al-Azhar University, Cairo
   
Accepted : 6/30/2016 9:26:00 AM    
Abstract :
One of the fruitful results of oral technological advancement in dosage forms is the orally disintegrating tablets (ODTs) as they disintegrate rapidly in the mouth and do not require water for administration. This work employed mixture design approach for developing and optimizing oral disintegrating tablets of a slightly water soluble drug, vardenafil hydrochloride. Three component mixture design was used to optimize the type and concentration of superdisntegrants, crosscarmellose sodium (X1), crosspovidone (X2) and sodium starch glycolate (X3) using water soluble dextrates (Emdex®) as a filler. Disintegration time, wetting time and t90 values for all formulations ranged from 33.69 to 208.68 s, 40.42 to 209.83 s and 80.04 to 484.63 s, respectively. According to the results, the selected variables have a strong influence on disintegration time, wetting time and t90 of the ODTs. The lowest disintegration time, wetting time and t90 were showed by ODTs formula composed of 1.72 % of crosscarmellose in combination with 4.28 % of crosspovidone. So, this formula was chosen as the optimized formula. Stability studies also showed that the optimized formula was stable under accelerated conditions. And, by comparing the selected formula with Prosolv® ODT G2 as a ready ODT system, it showed faster disintegration time and higher dissolution rate. Hence, the best superdisintegrants to be used with the water soluble dextrates are crosspovidone in combination with crosscarmellose sodium.

Ref : 343
Title : Geometrical engineering of magnetization reversal in Ni, Co and NiFe- based antidot lattices
Author(s) :
Name : Mohamed Salaheldeen mohamed Hassan
Address : Physics Department, Faculty of Science, Sohag University, 82524 Sohag, Egypt
   
Accepted : 6/30/2016 7:12:00 AM    
Abstract :

Antidot lattices can be used to artificially engineer the magnetic properties of thin films, however, a conclusive model that describes the coercivity enhancement in this type of magnetic nano-structures has so far not been found. Ni, Co and NiFe-based antidots thin films were grown by high vacuum thermal electron beam evaporation of a high purity Ni, Co and Permalloy layer, respectively deposited on the top surface of a nanoporous alumina membrane employed as patterned template, while the continuous films were deposited on a flat electropolished aluminium substrate. Geometrical characteristics as nanoholes diameter, holes inter-distance and the overall hexagonal symmetry of the antidot arrays are controlled through the original pores size and their arrangement from the starting alumina templates [1]. We prepared Ni, Co and NiFe thin films and patterned with layer thickness of 30 nm for NiFe and 50 nm for Ni & Co, each with circular antidot lattices with varying their geometric parameters. The morphological structure was observed by scanning electron microscope (SEM), the surface magnetic properties were investigated by magneto-optic Kerr effect (MOKE) and the bulk ones by vibrating sample magnetometry (VSM) techniques. To get a deeper insight into the magnetization reversal processes of the antidot nanostructures, we have also performed micromagnetic simulations by Mumax3 package with finite element discretization. On the basis of this extensive dataset, we are able to provide a model that can describe both the coercivity Hc and remanence Mr scaling over a wide range of geometric lattice parameters and the influence of different magnetic materials.
References

[1] F Beron, A. Kaidatzis, M.F. Velo, L.C.C. Arzuza, E.M. Palmero, R. P. del Real, D. Niarchos, K.R. Pirota, J.M. García-Martín, Nanoscale Res. Lett. 11 (2016) 86.


Ref : 342
Title : Advances in smart polymer nanocomposites for marine self-cleaning foul-release coatings
Author(s) :
Name : Dr. Mohamed S. Selim
Address : Egyptian Petroleum Research Institute (EPRI), Nasr city, Cairo, Egypt
   
Name : Prof. Dr. Sherif A El-Safty
Address : National Institute of Materials Science (NIMS) & Waseda University, Japan
   
Name : Shimaa A. Higazy
Address : Egyptian Petroleum Research Institute (EPRI), Nasr city, Cairo, Egypt
   
Accepted : 6/30/2016 7:16:00 AM    
Abstract :
Progress in materials science is strongly associated with the development of nanomaterials by energy-saving, environmentally friendly, and low-cost methods. Following the ban in 2003 on the use of tributyl-tin compounds in antifouling (AF) coatings, the search for an ecofriendly alternative has accelerated. Smart foul release (FR) nanocoatings are experiencing a renaissance owing to non-stick, ecological and economic returns. FR nanocomposite surfaces present moving targets to the functional groups of marine adhesives due to their conformationally mobile surfaces. Several functionl FR nanocomposite coatings have been developed to compete biofouling and biocorrosion with ecological and ecofriendly impacts than biocidal solutions. Incorporation of chosen inorganic nanofillers is more familiar due to the increased interaction at the filler-polymer interface for nanocomposites. Metallic nanoparticles (NPs) and their oxides have attracted great attention due to their unique morphology and size-dependent self-cleaning properties. The conception of modelling a novel series of FR nano-coatings combines two modes of prevention: chemical inertness and physical repelling of microfouling for maritime navigation applications. Long-term durability and FR performance represented an impacted development in modeling effective, stable and eco-friendly alternatives.

Ref : 340
Title : Effect of loading 5-phenyl-4H-1,2,4-triazole-3-thiol onto polypyrrole chitosan core shell nanoparticles on release rate, antimicrobial and antitumor activities.
Author(s) :
Name : Ahmed Ahmed Elbarbary
Address : Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
   
Name : Nehal Salahuddin
Address : Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt
   
Name : Mohamed labib salem
Address : Department of zoology, Faculty of Science, Tanta University, Tanta 31527, Egypt.
   
Name : Samar Elksass
Address : Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt.
   
Accepted : 6/30/2016 7:11:00 AM    
Abstract :
Polypyrrole chitosan core shell nanoparticles (PPC) were synthesized by in situ oxidation polymerization of pyrrole (Py) using FeCl3 in chitosan (CS) aqueous solution. 5-Phenyl-4H-1,2,4-triazole-3-thiol (I) was prepared and loaded into PPC core shell nanoparticles at two different temperatures (25, 80 °C). These core shell nanoparticle systems are insoluble in acidic medium and have good adsorption capacity. The release of loaded triazole was studied in different pH media (2, 7.4). The mechanism of triazole release was determined from zero-order release, first-order release, Higuchi model, Hixson-Crowell and Korsmeyer-Peppas kinetics equations. The antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis were evaluated. The potential cytotoxicity against Ehrlich ascites carcinoma (EAC) cells and liver (HEPG2) cell line in vitro was tested.

Ref : 339
Title : Synthesis, Characterization and AqueousProperties of a Newly Prepared Lignin-basedGraft Copolymer as a Drilling Mud Additive
Author(s) :
Name : Hany Mohammed Ahmed Abdel Ra-heem
Address : Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt
   
Name : Ibrahim Mohammed El-Sherbiny
Address : Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt
   
Name : Moneer Moneer Bsiony
Address : Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt and EBCA R&D Petroleum Center(Egyptian British Co. for Chemicals and Auxiliaries), Egypt.
   
Name : Magdy Abd El-Hamid Zahran
Address : Department of Organic Chemistry, Facultyof Science, Menoufia University,Egypt
   
Accepted : 6/30/2016 7:07:00 AM    
Abstract :
This study involves a free radical graft copolymerization of lignosulfonates (LS) with 2-propenamide (Am), propenoic acid (AA), and methylene-bis-acrylamide (MBAm) in the presence of hydrogen peroxide as the initiator to produce LS-g-p(AA-co-Am-co-MBAm) copolymer. The resulting copolymer was characterized by various techniques such as infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA). Viscosity measurements of the copolymer solution, pH values, solid content, gravimetric conversion and mud properties were determined. The effect of various experimental conditions on the characteristics of the developed copolymer was also investigated. Moreover, the performance of the resulting LS-g-p(AA-co-Am-co-MBAm copolymer as a pH controlling agent for water-base mud was evaluated. The obtained results revealed that the newly synthesized copolymer has a remarkable pH control performance at different temperatures.
Keywords: Drilling fluids, Water-based mud, Copolymer, Multifunctional, pH control

Ref : 338
Title : Composition Effects on Structural, Morphological and Optical Properties of ZnxCd1-XS Nanoparticles
Author(s) :
Name : Ahmed G. Abd-Elrahim
Address : Assiut University, Assiut Egypt
   
Name : Mohamed A. Osman
Address : Assiut University, Assiut Egypt
   
Name : Waleed A. El-said
Address : Assiut University, Assiut Egypt
   
Name : Aly A. Othman
Address : Assiut University, Assiut Egypt
   
Accepted : 6/30/2016 7:06:00 AM    
Abstract :
Monodispersed ZnxCd1-xS (x = 0, 0.36, 0.45, 0.58 and 1), cubic nanoparticles (NPs) with crystallite size (D) in the range 2 to 3 nm were prepared at room temperature by chemical precipitation method. Composition effect on structural, morphological changes, photoluminescence and optical absorption behavior have been investigated using x-ray diffraction, high resolution transmission electron microscope, optical absorption, and photoluminescence (PL) spectra, Fourier transform infrared and Raman spectroscopy. The optical energy gap of ZnxCd1-xS NPs was tuned to a higher energy by increasing Zn content, as well as systematic shifting of the x-ray diffraction peaks to higher angles indicating the formation of homogenous alloys of ZnxCd1-xS NPs. In addition, the linear dependence of lattice constants on Zn content, also demonstrates the compositional homogeneity of the ternary alloy in accordance with Vegard’s law. The linear dependence of Raman shift on Zn content reveals that the optical phonons in the ZnxCd1−xS NPs are the one phonon mode. PL emission spectra at excitation wavelengths 325 and 370 nm, reveal no change in the position of the main emission band and an enhancement in the PL intensity with increasing Zn content. The mechanism of PL was explained and discussed.

Ref : 336
Title : Dependence of Photoluminescence and Optical Absorption Behavior of EDTA-Capped Zn0.78Cd0.22S Nanoparticles on thermally induced Structural phase transition, Morphological Changes and UV irradiation dose
Author(s) :
Name : Mohamed A. Osman
Address : Assiut University, Assiut Egypt
   
Accepted : 6/30/2016 7:03:00 AM    
Abstract :
In this paper, we conduct a first trial study of size-dependent structural phase transition and morphological changes via thermal annealing of EDTA capped Zn0.78Cd0.22S nanoparticles (NPs). In addition, we focused our attention on the interrelation between these changes and photoluminescence (PL) and optical absorption behavior of annealed and UV irradiated samples synthesized by chemical precipitation method at ambient temperature with a crystallite size (DSch.) ≈ 2 nm. The samples were characterized using XRD, FTIR, Raman and XRF spectra, and HRTEM. It was found that increasing annealing temperature (Ta), results in structural phase transition from polycrystalline cubic Zn0.78Cd0.22S to single crystalline hexagonal structures of ZnO due to size driven phase transition caused by sintering and grain growth via annealing process in air. The crystallization process results in the reduction of the internal local strain, the dislocation density, accompanied by the increase in the particle size and red shift of the optical band gap (Eg). Normalized PL spectrum of as-prepared nanopowder at excitation wavelength 325 nm reveals UV emission bands at 362 and 394 nm and blue emission bands at 443 nm. With increasing Ta up to 500 ºC, no noticeable change in the PL intensity was observed; further increase in Ta results in an enhancement of PL intensity associated with the evolution of new green emission band at 515 nm. In the case of Zn0.78Cd0.22S NPs colloidal solution, PL spectrum reveals emission bands at 370, 403, 453, 489, 537 and 575 nm. On the light of the obtained results, trapping, and recombination levels in Zn0.78Cd0.22S NPs have been identified and an energy band diagrams were suggested. It was noticed that UV irradiation of colloidal solution leads to the increase of Eg and enhancement in PL intensity due to the decrease in the particle size and the reduction of localized tail state width. The observed enhancement in PL intensity was ascribed to the reduction in the particle size (i.e. the improvement of quantum size effect) by photo-corrosion, surface modification by photopolymerization, the formation of photo-passivated layers, as well as oxygen adsorption on the surface of Zn0.78Cd0.22S NPs.

Ref : 335
Title : Influence of Mn-Doping on Structural, Morphological, Photoluminescence, and Magnetic properties of ZnO Nanostructures Synthesized by Ice-Bath Assisted Sonochemical Method
Author(s) :
Name : Aly Abd-Elhamid Othman
Address : Assiut University, Assiut Egypt
   
Name : Mohamed Abd-Elhamid Osman
Address : Assiut University, Assiut Egypt
   
Name : Eslam M. M. Ibrahim
Address : Sohag University, Sohag, Egypt
   
Name : Manar A. Ali
Address : Assiut University, Assiut Egypt
   
Accepted : 6/30/2016 7:02:00 AM    
Abstract :
This work displays the synthesis of Mn-doped ZnO (Zn1-xMnxO, x = 0.00, 0.01, 0.02, 0.03, 0.04, and 0.05) nanostructures capped with polyethylene glycol (PEG) by ice-bath assisted sonochemical technique. The impact of Mn-doping on structural, morphological, optical, and magnetic properties of ZnO nanostructures is studied. X-ray diffraction (XRD) analysis of all samples under study reveals the formation of hexagonal wurtzite structure of ZnO phase. The increase in Mn concentration up to 0.02 results in a shift of the diffraction angle to the higher values, a contraction of the Zn-O bond length, the enhancement of the unit cell volume and the micro-strain, as well as a reduction of the corresponding crystallite size, and vice versa at Mn content above 0.02. The morphological study shows that the samples possess a mixture of nanosheets and nanorods. In addition, the increase in Mn content leads to the improvement of an anisotropic growth in a preferable orientation to form well-defined edge rods at Mn content of 0.04. UV-vis absorbance spectra show that the exciton peak in the UV region is blue shifted as a result of incorporation of Mn ions into ZnO lattice. Photoluminescence (PL) spectrum of ZnO nanopowders at excitation wavelength ("λ" _"ex" ) = 325 nm reveals that the main UV emission band at 397 nm is attributed to exciton recombination of photo-generated carriers, whereas PL spectrum at λex = 380 nm reveals that the main orange band at 598 nm is ascribed to oxygen interstitials. In addition, two energy band diagrams were suggested for identifying various trapping and recombination levels in ZnO nanopowders. Doping ZnO with Mn ions leads to the reduction of PL intensity because of increasing the non-radiative recombination centers. The magnetic measurements show that Mn-doped ZnO nanostructures exhibit the ferromagnetic ordering at room temperature, as well as the Mn content can affect the ferromagnetic behavior of the samples effectively.

Ref : 334
Title : Synthesis and Evaluation of Some New Substituted Thienopyrimidine Derivatives as Potential Anticancer and Antimicrobial Agents
Author(s) :
Name : Shrouk Mahmoud Abdel-Wahaab
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dmanhour, Damanhour, Egypt
   
Name : Raafat Soliman Ali
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
   
Name : Alaa Aly Abdel-Maksoud El-Tombary
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
   
Name : Omaima Gaber Shabaan
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
   
Name : Abeer Abd El-Wahab
Address : Genetic Engineering and Biotechnology Research Institute (GEBRI), the City of Scientific Research and Technology Applications (SRTA-City), Borg El-Arab, Alexandria, Egypt
   
Accepted : 6/29/2016 9:38:00 AM    
Abstract :
Synthesis and Evaluation of Some New Substituted Thienopyrimidine Derivatives as Potential Anticancer and Antimicrobial Agents

S.M. Abdel-Wahaab1, R. Soliman2, A.A. El-Tombary2, O.G. Shaaban2 and A.E. Abdel wahab,3
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dmanhour, Damanhour, Egypt
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
3 Genetic Engineering and Biotechnology Research Institute (GEBRI), the City of Scientific Research and Technology Applications (SRTA-City), Borg El-Arab, Alexandria, Egypt
The increasing number of neoplastic diseases together with the accompanied high mortality rates has stimulated the search for new structure leads that might be of use in designing novel anticancer drug. Also patients suffering from neoplastic disorders and receiving chemotherapeutic treatment are more likely to get microbial infections due to subsequent depression of the immune system. Since thienopyrimidines and their fused ring systems are potential bioactive molecules as they are structural analogs of biogenic purines and can be considered as potential nucleic acid antimetabolite [1]. Also, azoles are constituents of many bioactive antitumor and antimicrobial heterocyclic compounds [2]. In addition, The combination of two pharmacophores on the same scaffold is a well-established approach to the synthesis of more potent drugs [3], the objectives of our work have been directed toward the design and synthesis of some novel 3-substituted-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives [4] which may serve as leads for designing novel anticancer or antimicrobial agents. The synthetic procedures adopted to obtain the target compounds are illustrated in the following scheme.

Scheme 1: synthesis of target compounds (2-9)
References
1. N.S. Habib, R. Soliman, A. A. El-Tombary, S.A. El-Hawash, O. G. Shaaban, Med. Chem. Res. 22 (2013) 3289-3308.
2. A.P. Keche, G. D. Hatnapure, R. H. Tale, A. H. Rodge, V. M. Kamble, Bioorg. Med. Chem. lett. 22 (2012) 6611-6615.
3. A.D. Pillai,P. O. Rathod, F. P. X, M. Patel, M. Nivsarkar, K. K. Vasu, H. Padh, V. Sudarsanam, Biochem. Biophys. Res. Commu. 301 (2003) 183-186.
4. S. M. Abdel-Wahaab; M. S. Dissertation, Alexandria University (2014).



Ref : 333
Title : Bioethanol production from agricultural wastes
Author(s) :
Name : ADELODUN ONIYIDE ADELODUN
Address : Bollytek Technologies Services, Nigeria
   
Accepted : 6/29/2016 8:16:00 AM    
Abstract :
Due to rapid growth in population and industrialization, worldwide ethanol demand is increasing continuously. Conventional crops such as corn and sugarcane are unable to meet the global demand of bioethanol production due to their primary value of food and feed. Therefore, lignocellulosic substances such as agricultural wastes are attractive feedstocks for bioethanol production. Agricultural wastes are cost effective, renewable and abundant. Bioethanol from agricultural waste could be a promising technology though the process has several challenges and limitations such as biomass transport and handling, and efficient pretreatment methods for total delignification of lignocellulosics. Proper pretreatment methods can increase concentrations of fermentable sugars after enzymatic saccharification, thereby improving the efficiency of the whole process. Conversion of glucose as well as xylose to ethanol needs some new fermentation technologies, to make the whole process cost effective. In this review, available technologies for bioethanol production from agricultural wastes are discussed.

Ref : 332
Title : An in vitro study to evaluate the effect of a copper glycine-glutamate-glutamate complex as an anti-inflammatory drug in rheumatoid arthritis
Author(s) :
Name : Pumeza Gogwana
Address : Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
   
Name : Graham E. Jackson
Address : Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa
   
Accepted : 6/29/2016 5:34:00 AM    
Abstract :
Rheumatoid arthritis (RA) is described as a chronic inflammatory disease which may result in the destruction of bone and cartilage. The disease is characterized by altered serum copper concentrations. Thus, administration of molecules containing copper which can target inflammatory pathways might be beneficial in the treatment of the disease.
The present study was undertaken to examine the efficacy of copper-peptide complexes which can be administered transdermally as therapeutic agents to relieve inflammation associated with RA. Potentiometric experiments were conducted to measure the formation constants of glycine-glutamate-glutamate (GEE) with Cu(II), Ni(II) and Zn(II) at 25 oC with 0.15M NaCl. The speciation of the formed complexes was calculated using the Equilibrium Simulation for Titration Analysis computer program. UV-visible spectroscopy was used to predict the structure of the formed species. The permeability of CuGEE through the skin was estimated by measuring the rate of the copper complex diffusion through the ceramose membrane. The degree of lipophilicity and mobility of the complex was evaluated using octanol/water partition coefficients.

Ref : 331
Title : Synthesis and Characterization of Copper(II) Complexes Containing N3S2 donors Ligand. Catechol Oxidase and Phenoxazinone Synthase Biomimetic Catalytic Activity
Author(s) :
Name : Abd El-Motaleb M. Ramadan
Address : Chemistry Department, Faculty of Science, Kafr El-Sheikh University, Kafr El-Sheikh Egypt
   
Name : Asmaa Ibrahium
Address : Chemistry Department, Faculty of Science, Aswan University, Aswan, Egypt
   
Accepted : 6/29/2016 5:32:00 AM    
Abstract :
The reaction of the pyridine based ligand, L, with copper(II) salts (CuX2; X = Cl¯, Br¯, NO3¯, AcO¯ and ClO4¯) in a 1:1 ratio in ethanol gives a series of copper(II) complexes having the molecular formulae of [CuLX]X (X = Cl, Br, NO3) and [CuL]X2 (X = AcO and ClO4). Structural characterization of the pure isolated complex species was achieved by several physicochemical methods, namely elemental analysis, electronic spectra, IR, ESR, molar conductivity, thermal analysis (TAG & DTG), and magnetic moment measurements. The stereochemistry, the nature of the copper(II) chelates, and the catalytic reactivity are markedly dependent upon the type of counter anions incorporated in the complex molecule. Mimicking copper-oxidase enzymes namely catechol oxidase and phenoxazinone synthase was investigated and the results obtained demonstrated that, there is a correlation between the structural properties of these copper(II) complexes and the oxidase biomimetic catalytic activities. Catalytic studies demonstrate that the reported copper(II) complexes are suitable as catalysts for the catalytic aerobic oxidation of 3,5-di-tert-butylcatechol (3,5-DTBCH2) to 3,5-di-tert-butyl-benzoquinone (3,5-DTBQ) (catechol oxidase activity), and o-aminophenol (OAPH) to 2-aminophenoxazine-3-one (APX) (phenoxazinone synthase activity) with dioxygen at ambient condition in good yields. The probable mechanistic implications of both catalytic systems are discussed.


Ref : 330
Title : Engineered Sorbent of Magnetic Iron Oxide Nanoparticles-Urea-Activated Carbon for Potential Magnetic Solid Phase Extraction of Uranium (VI) from Aqueous Solution
Author(s) :
Name : Mennatllah S. Header
Address : Faculty of Sciences, Chemistry Department, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt
   
Accepted : 6/27/2016 3:35:00 PM    
Abstract :
A novel magnetic sorbent material was designed on the basis of chemical grafting of nano-magnetite (Nano-Fe3O4) with activated carbon (AC) via urea as a cross-linking intermediate for the formation of Nano-Fe3O4-Urea-AC. By characterizing of the magnetic sorbent was carried out by different instrumentation such as SEM, HR-TEM, TGA, and FT-IR. The designed sorbent was found to maintain its magnetic properties and nanosize structure with the particle size in the range of 8.65-14.06 nm. The surface area was identified as 389 m2/g based on the BET method determination. The sorption process of uranyl ions using this sorbent from aqueous solutions was studied and evaluated to confirm its sorption ability in different experimental condition. uranyl ions sorption increased with increasing in pH value and the maximum percentage removal was reached and established at pH 5.0. A number of key variables affecting the removal and sorption process of uranyl ions by Nano-Fe3O4-Urea-AC sorbent was studied and optimized using the batch technique and these include the contact time, Nano-Fe3O4-Urea-AC sorbent dosage, reaction temperature, the initial uranyl ions concentration and interfering anions and cations.

Ref : 329
Title : SEASONAL VARIATION OF THE ESSENTIAL OIL OF FRAXINUS ANGUSTIFOLIA VAHL AND ITS ANTIMICROBIAL PROPERTIES
Author(s) :
Name : Zouaghi Nafila
Address : Laboratoire d’étude et de développement des techniques de traitement et d’épuration des eaux et de gestion environnementale. Ecole Normale Supérieure, Kouba, Algeria
   
Name : Bellal Cherifa
Address : Laboratoire d’étude et de développement des techniques de traitement et d’épuration des eaux et de gestion environnementale. Ecole Normale Supérieure, Kouba, Algeria
   
Name : Cavaleiro Carlos
Address : CNC.IBILI, Faculty of Pharmacy, University of Coimbra, Azinhaga de S. Comba 3000-354 Coimbra, Portugal
   
Name : Youfi Mohamed
Address : Laboratoire des Sciences Fondamentales, Université Amar Telidji, Laghouat, Laghouat, Algeria.
   
Name : Nadjemi Boubekeur
Address : Laboratoire d’étude et de développement des techniques de traitement et d’épuration des eaux et de gestion environnementale. Ecole Normale Supérieure, Kouba, Algeria
   
Accepted : 6/26/2016 10:13:00 AM    
Abstract :
Fraxinus angustifolia Vahl, (Oleaceae) was studied for the seasonal influence on the volatile oil yield and composition. The essential oil was isolated by hydrodistillation and the composition was assessed by GC/MS and GC-FID analysis.Essential oil yield was higher in early summer (June .0.0416 % and 0.0412 % in July) comparing with spring yields (March 0.020%), April 0.013 % and May 0.021 %). Concerning the oil composition qualitative and quantitative differences were observed: plant material collected during winter produced oils with relevant amounts of abietatriene (10.9%) and α-cedrol (4.9%) or E-caryophyllene (13.0%), linalool (4.3%) and Germacrene D (4.0%). Plant material collected during spring rendered oils dominated by methyldocosane (30.2%) and pentacosane (28.5%). In early summer the concentration of the diterpenes isopimaradiene and manoyl oxide raise but not exceeding (20.1%) and (5.6%) respectively. α-Cadinol and -cadinene concentrations raise in summer to 16.6% and 5.9%, respectively.
Oils were also tested against four bacteria (Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), using the Kirby Bauer disk-diffusion method. All bacteria were susceptible at 300 µg of volatile oil.


Ref : 327
Title : Micro minerals profile of forbs and grasses in seed set stagefor grazing ruminants in Sudan
Author(s) :
Name : Sahar Ezzat
Address : College of Forestry and Range Sciences, Sudan University of Science and Technology, Soba, Khartoum, Sudan
   
Name : B. Fadlalla
Address : College of Forestry and Range Sciences, Sudan University of Science and Technology, Soba, Khartoum, Sudan
   
Name : Hala Ahmed
Address : College of Forestry and Range Sciences, Sudan University of Science and Technology, Soba, Khartoum, Sudan
   
Accepted : 6/26/2016 7:50:00 AM    
Abstract :
This study was conducted to determine the status of some micro minerals notably iron, copper, zinc, cobalt and nickel, in forbs and grasses in the seed set stage for sheep grazing on natural range land, at Sheikan Locality, North Kordofan State, Sudan in the year 2011 and 2012. Changes in mineral concentrations with maturity often reflect increases in the proportion of stem to leaf with stems showing lower mineral concentrations than young leaves. Sampling of plants’ shoots (leaves and stems) were picked randomly by hand according to diet selected by sheep and ICP was used to determine minerals. Our data indicated a higher content of micro minerals in forbs compared with grasses (P<0.05). It was concluded that the rangelands of North Kordofan State, containing a mixture of grasses and forbs, are good sources of micro minerals that can meet the requirements of sheep.
Key words: Trace-mineral, seed set stage, forbs, grasses.

Ref : 326
Title : Equilibrium and potentiometric studies of diorganotin(IV) with 1-benzoyl(1,2,4-triazol-3-yl)thiourea
Author(s) :
Name : wafaa mahmoud hosny
Address : cairo university, faculty of science, department of inorganic chemistry, Giza Sq., Giza, Egypt
   
Accepted : 6/25/2016 7:28:00 PM    
Abstract :
The interactions of 1-benzoyl(1,2,4-triazol-3-yl)thiourea (BTTU) with dimethyltin(IV) (DMT), dibutyltin(IV) (DBT) and diphenyltin(IV)(DPT) were investigated at 25oC in 50% ethanol–water mixture and 0.1M ionic strength. The stepwise formation constants of the 1:1 and 1:2 complexes formed in solution were calculated using the non-linear least-square program MINIQUAD-75. The concentration distribution of the various complex species was evaluated as a function of pH. The ligand and its DMT complex as 1:2 [Sn: BTTU] has been synthesized and characterized by different analyses methods as elemental analyses, IR, 1HNMR and molar conductance measurements. The synthesized complex screened in vitro against some bacteria and fungi.

Ref : 325
Title : Study of the photocatalytic degradation of organic pollutants in the presence of titanium dioxide and natural support
Author(s) :
Name : Zohra.Medjdoubi, Hayet.Douichen, Mohamed. Hadjel and Karima Baghdad
Address : Department of Chemistry, Faculty of Exact and Applied Sciences University of Oran 1-Algeria
   
Accepted : 6/25/2016 5:14:00 PM    
Abstract :
The aqueous effluents resulting from the petrochemical and paper industry often have a high organic pollutant load hardly biodegradable.Their decontamination by conventional techniques proves ineffective in some cases.In this work, we studied two different methods for the removal of furfural aqueous solutions.The furfural is used as solvent in the Arzew refinery and often is in the releaseswater same after treatment. In the first part, we are interested in the study of adsorption on a sedimentary material called Diatomite from the region Sig "west of Algeria."The raw diatomite was treated and characterized (composition, XRD, IR, SEM, adsorption of nitrogen and ATG). Then it is used for the removal of furfural aqueous effluents. An isothermal study to show that the adsorption capacity for the diatomaceous earth treated with acid and then calcined at 1000°C is higher.In the second part, we tested the degradation of furfural by heterogeneous photocatalysis using system UV / TiO2-Diatomite. The results allowed us to show that heterogeneous photocatalysis on TiO2-Diatomite mixture is effective in removing furfural industrial wastewater.

References
1.Y.Xia, F.Li, Y.Jiang, M.Xia, B. Xue, Y. LiKey;,Applied Surface Science 303 (2014) 290–296.
2.Y.Jia, W.Hana, G.Xiong, W.Yang; ,Journal of Colloid and InterfaceScience 323 (2008) 326–331.

Ref : 324
Title : Approaches toward improving some of medicinal drugs such anti-inflammatory, anti-biotics and anti-diabetic agents.
Author(s) :
Name : Shaaban K. Mohamed
Address : Manchester Metropolitan University, Manchestyer, M1 5GD, UK
   
Accepted : 6/25/2016 10:29:00 AM    
Abstract :
Historically, no doubt, the ancient Egyptians since 2000 BC were the first use for the salicylate rich plants or what so called later as Aspirin to reduce fevers [1]. This natural Asprin extract was used till late eighteen century and was first synthesized on 1853. This led to discover many of other non-steriodal anti-inflammatory drugs (NSAIDs) based acetic or acidic functional group such as Ibuprofen, Indomethacin, Naproxcin…etc. On long term administration of NSAIDs showed serious adverse reaction mainly as gastro-intestinal (GI) incidences [2]. In this study we try to overcome such undesired side effects by modifying the chemical structures of such drugs. The study was extended to develop new anti-diabetic agents based metformin core structure as well. On other hand a new Nano fabrication has been designed to improve the efficacy of some anti-biotic such as amoxicillin and neomycin using silver nitrate Nano-particles as a capping agent.

References:
1- Nunn, John F. (1996). "7". Ancient Egyptian Medicine. Norman, OK, USA: University of Oklahoma Press. pp. Ch. 7, Table 7.2. ISBN 0-8061-2831-3.
2- Rainsford, K.D., Subcell Biochem., 2007, 42, 3-27.


Ref : 323
Title : Environmental Impacts of pastoralist movement on the natural rangeland in Butana area, Sudan
Author(s) :
Name : Hala Ahmed Hassan Mohammed
Address : Sudan University of Science and Technology, College of Forestry & Range Sciences, Department of Range Science, Sudan
   
Name : AbdelazizAbdelfattah Hashim
Address : Agricultural Research Corporation (ARC), Agricultural Economics and Policy Research Center, Sudan
   
Name : Babo Fadlalla
Address : Sudan University of Science and Technology, College of Forestry & Range Sciences, Department of Range Science, Sudan
   
Name : Sahar Ezzat
Address : Sudan University of Science and Technology, College of Forestry & Range Sciences, Department of Range Science, Sudan
   
Accepted : 6/25/2016 7:50:00 AM    
Abstract :
This study aimed to identify the environmental impact of pastoralist movement on the natural rangeland in Butana area of Sudan. A field survey was started in the first of July and ended late September 2011. A random sample of 407 pastoralists’ households in Butana area was chosen to collect primary data through a structured questionnaire. Descriptive statistics was used for data analysis. The data were coded, summarized, tabulated and processed. Analysis was conducted using (SPSS) computer program. The results were presented in form of frequency distribution. It was found that (80%) of pastoralists reported that rangeland condition was poor. The majority of pastoralists (79%) said that the current rangeland problem is soil degradation /erosion. Also, (88%) said that dry season / drought has the major effect on the rangeland.
In addition, all respondent pastoralists reported that new plant species have invaded the area like Cymbopogon spp. About (77%) of respondents said expansion of rain-fed agriculture in the study area reduced the area of the natural rangeland and that there were conflicts between farmers and herders on rangeland. The study recommended rangeland should be improved by government through availing animals’ services, reseeding and proper distribution of water points.
KEY WORDS: Rangeland, agricultural expansion, conflicts, range deterioration

Ref : 322
Title : Antimicrobial activity of azo-dye derivatives of β-oxoanilides.
Author(s) :
Name : Ibrahim Abdel-Motaleb Mousa
Address : South Valley University-Faculty if Science at Qena-Chemistry Department
   
Accepted : 6/25/2016 7:43:00 AM    
Abstract :
Acetoacetanilide of sulfadiazine (1) was prepared from sulfadiazine with ethylacetoacetate, then reacted as a coupler with diazonium salt to give azo-dye derivatives 2a-d. Four compounds were screened for antibacterial activity against gram positive bacteria (Enterococcus Faecalis) and gram negative (E. Coli) with Cloroamphenicol 30 μg as control. Some of the tested compounds showed significant antibacterial activity. The U.V. spectra of the isolated products were examined. IR, 1H-NMR, mass spectral data, and elemental analysis elucidated the structures of all the newly synthesized compounds.

Ref : 320
Title : Determining the quality of rainwater in the Algiers region for reuse. Physico-chemical characterization.
Author(s) :
Name : Benrejdal Fazia, Haddad Habiba and Ghoualem Hafida
Address : Laboratory of Electrochemistry-Corrosion, Metallurgy and Inorganic Chemistry. Faculty of Chemistry. University of Sciences and Technology.Houari Boumediene. Box N°32 El-Alia. Bab-Ezzouar. Algiers. Algeria.
   
Accepted : 6/24/2016 10:22:00 AM    
Abstract :
Water is essential with the life. Its quality was always an element essential to an environment favorable to health. Our work, a detailed attention is given to rainwater recovered on the area of Algiers. The objective of this work is to contribute to the characterization of rainwater then a hydrochimic study to know the quality of this water which is usable in multiple fields. The various parameters taken into account during the characterization of the physical and chemical parameters are: pH, turbidity, conductivity, MES, DCO and ions NH4+, NO3-, NO2-, PO43 -, Cl -, SO42 -, Na +, K +, Ca2 +, Mg2 +.
Keywords: Rainwater, physicochemical characterization, reuse.

Ref : 319
Title : Synthesis, Spectroscopy and Antimicrobial Activity of Iron(III), Manganese (II) and Cupper(II) complexes Involving Some New Symmetrical and dissymmetrical Schiff Bases
Author(s) :
Name : Hussin Elshahat Hussin Mohamed Elkik
Address : Chemistry Department, Faculty of Science at Qena, South Valley University, Qena, 83523,
   
Name : Moustafa Hassan Mohamed Abou-El-Wafa
Address : Chemistry Department, Faculty of Science at Qena, South Valley University, Qena, 83523,
   
Accepted : 6/23/2016 6:46:00 AM    
Abstract :
Schiff bases are an interesting class of ligands having numerous applications [1,2].The symmetrical Schiff baseshave been prepared by the interaction ofethylene-1,2-diamine with 4-methoxybenzaldehyde (H1), 2-hydroxyacetophenone (H2) or by interaction ofo-phenylenediamine with 2-hydroxybenzaldehyde (H3) and 4-hydroxy -benzaldehyde (H4). Whereas, thedissymmetrical Schiff bases have been synthesized by condensationof o-phenylenediamine, o-hydroxybenzaldehyde and p-methoxybenzaldehyde (H5), p-nitrobenzaldehyde (H6) or o-chlorobenzaldehyde (H7) (see Fig. 1). Furthermore,their Fe(III), Mn(II) and Cu(II) complexes have been synthesizedin a molar ratio 1:1 (metal: ligand).All obtained compounds have been characterized by elemental analysis, FT-IR, UV-Vis spectra.These complexes have been screened for their biological activity against various bacterialand fungal strains. All the ligands show higher activity after complexation.


References:
[1](a) M.K. Taylor, J. Reglinski, D. Wallace, Polyheron 23 (2004) 3201, (b) S. Yamada, Coordin. Chem. Rev. 192 (1999) 537.
[2] U.M. Rabie , A.S.A. Assran, M.H.M. Abou-El-Wafa,J. Mole. Struct.872 (2008) 113.

Ref : 318
Title : Design, Synthesis and Evaluation of Antioxidant Capacity and Lipoxygenase Inhibiton of Some New 2-Phenylindole Derivatives
Author(s) :
Name : Haydi Ahmed Saher El-Bordiny
Address : assistant lecturer , pharmaceutical chemistry departement,Faculty of Pharmacy, Damanhour University
   
Name : Mostafa Mohamed Mahmoud El-Miligy
Address : lecturer of pharmaceutical chemistry, Faculty of Pharmacy, Alexandria University
   
Name : Shaymaa Emam Kassab
Address : lecturer of pharmaceutical chemistry, Faculty of Pharmacy, Damanhour University
   
Name : Hoda Gamal Eldin Daabees
Address : professor of pharmaceutical chemistry and dean of Faculty of Pharmacy, Damanhour University
   
Name : Soad Abdel-Hamid El-Hawash
Address : professor of pharmaceutical chemistry, Faculty of Pharmacy, Alexandria University
   
Accepted : 6/21/2016 6:26:00 PM    
Abstract :
Antioxidants and lipoxygenase (LOX) inhibitors have attracted attention intially as potential agents for the treatment of inflammatory diseases and their therapeutic potential has been expanded to certain types of cancer and cardiovascular diseases (1,2). In addition, it has been iteratively confirmed that compounds of LOX inhibition potential are with consistent antioxidant activity (3,4). Moreover, literature survey revealed that 2-phenylindole derivatives displayed antioxidants and LOX inhibitory activities (5). Accordingly, the objective of this work was directed to design and synthesize a new series of 3-substituted 2-phenylindoles aiming to explore new structural candidates that displayed dual antioxidant/LOX inhibitory activities which might be of value for the development of new class of potent anti-inflammatory with better safety profile. The target compounds were constructed to comprise the anti-inflammatory pharmacophore pyrazoline or isoxazoline moiety directly attached to indole scaffold at position-3 (compounds 4-8). These compounds were evaluated for their antioxidant and in vitro LOX inhibitiory activities using ascorbic acid and quercetin as references. The results revealed that most of the tested compounds exhibited promising antioxidant and LOX inhibitory activities higher than or comparable to the reference drugs. The synthetic procedures adopted to obtain the target compounds are illustrated in the following scheme.

Ref : 317
Title : Construction and performance characteristics of chemically modified carbon paste electrodes for the selective determination of Co(II) ions in water samples
Author(s) :
Name : Noha Mohsen Hanafy Mahmoud, Tamer Awad Ali, Gehad. G.Mohamed, Mohamed. M. Omar
Address : 42A, Ibrahim Baher Zaglol, Manial, Cairo, Egypt
   
Accepted : 6/21/2016 4:02:00 AM    
Abstract :
The construction, performance characteristics and application of Co(II)-chemically modified carbon paste electrodes (CMCPEs) based on bis(salicylaldehyde)-o-phenylenediamine (Schiff base I, SalophH2; ionophore A), N-salicylidene-o-aminophenol (Schiff base II, SaphH2, ionophore B), [Co(Saloph)] complex (ionophore C) and [Co(Saph)OH2] complex (ionophore D) are reported in this paper. The CMCPEs are prepared by incorporating of A, B, C and D ionophores into a plasticized carbon paste electrodes to form electrodes I, II, III and IV sensors, respectively. The prepared electrodes exhibit Nernstian slope of 29.20±1.13, 28.20±2.07, 29.90±0.26 and 28.80±1.04 mV decade-1 towards Co(II) ion over a wide concentration range of 1.0×10-7-1.0×10-2, 7.9×10-7 - 1.0×10-2, 4.9×10-8 - 1.0×10-2 and 5.1×10-7 - 1.0×10-2 mol L-1 with a detection limit of 1.0×10-7, 7.9×10-7, 4.9×10-8 and 5.1×10−7 mol L-1 at pH range from 3.0 - 8.0, 3.5 - 7, 2.0 - 8.0 and 2.5 - 7.5 for electrodes I, II, III and IV, respectively. The electrodes showed good selectivity for Co(II) ion toward a wide variety of metal ions. The proposed electrodes were successfully applied for the determination of Co(II) ion in real spiked water samples and the results obtained compared well with those obtained using inductively coupled plasma atomic emission spectrometry (ICP-AAS).

Ref : 316
Title : Bioethanol production from agricultural wastes
Author(s) :
Name : ADELODUN ONIYIDE ADELODUN
Address : BOLLYTEK TECHNOLOGIES SERVICES, Nigeria
   
Name : OMOTOSHO RASHEED AKOREDE
Address : UNIVERSITY OF IBADAN,DEPARTMENT OF SCIENCE, Nigeria
   
Accepted : 6/20/2016 9:21:00 AM    
Abstract :
Due to rapid growth in population and industrialization, worldwide ethanol demand is increasing continuously. Conventional crops such as corn and sugarcane are unable to meet the global demand of bioethanol production due to their primary value of food and feed. Therefore, lignocellulosic substances such as agricultural wastes are attractive feedstocks for bioethanol production. Agricultural wastes are cost effective, renewable and abundant. Bioethanol from agricultural waste could be a promising technology though the process has several challenges and limitations such as biomass transport and handling, and efficient pretreatment methods for total delignification of lignocellulosics. Proper pretreatment methods can increase concentrations of fermentable sugars after enzymatic saccharification, thereby improving the efficiency of the whole process. Conversion of glucose as well as xylose to ethanol needs some new fermentation technologies, to make the whole process cost effective. In this review, available technologies for bioethanol production from agricultural wastes are discussed.


Ref : 315
Title : Characterization of coordination compounds of some transition metal ions with Schiff base ligand derived from dibenzoyl methane
Author(s) :
Name : Walaa H. Mahmoud
Address : Chemistry Department, Faculty of Science, Cairo University, Giza, 12613 Egypt.
   
Name : Omnia Y. El-Sayed
Address : Chemistry Department, Faculty of Science, Cairo University, Giza, 12613 Egypt.
   
Name : Gehad G. Mohamed
Address : Chemistry Department, Faculty of Science, Cairo University, Giza, 12613 Egypt.
   
Accepted : 6/20/2016 7:05:00 AM    
Abstract :
A new series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes were prepared with tetradentate ligand derived by condensation of
2-aminophenol with dibenzoylmethane. The Schiff base H2L (2-2’-((1Z,1Z’)-(1,3-diphenyl propane-1,3 diylidene) bis (azanylylidene) diphenol) and its binary metal complexes were characterized by standard physicochemical procedures i.e. elemental analysis, FT-IR, UV–Vis, thermal analyses (TGA/DTG), magnetic susceptibility and conductometric measurements. On the basis of these studies, a six coordinated octahedral geometry for all these complexes has been proposed expect Ni(II) complex is tetrahedral geometry. The Schiff base and its complexes have been screened for their antimicrobial activity against a number of bacteria organisms as Streptococcus pneumonia, Bacillus Subtilis, Pseudomonas aeruginosa and Escherichia coli and fungi Aspergillus fumigates, Syncephalastrum racemosum, Geotricum candidum and Candida albicans by disk diffusion method. The Cd(II) complex has potent antimicrobial activity. Anticancer activity of the ligand and its metal complexes are evaluated in human cancer (MCF-7 cells viability). The Cr(III) complex exhibit higher activity than other complexes and ligand .
Key word
Schiff base; FT-IR, UV–Vis; Binary metal complexes; Antimicrobial activity; Anticancer activity

Ref : 314
Title : The Potentiostatic Deposition of Metallic Molybdenum from Aqueous Electrolytes Containing Molybdate Ions in presence of Acetic acid
Author(s) :
Name : Samira Cafarova, Mahmoud Elrouby, Aliyev A.Sh.
Address : ANAS, Institute of Catalysis and Inorganic Chemistry, Baku, Azerbaijan
   
Accepted : 6/20/2016 6:26:00 AM    
Abstract :
In this study, the electroreduction of metallic molybdenum from aqueous solution of molybdate ions in presence of acetic acid was achieved potentiostatically in a facile way. The kinetics and the mechanism of the electrodeposition nucleation of molybdenum deposits are studied and explored. It is observed that, the process of the electrodeposition nucleation starts at -0.6 V as illustrated from the figure. The shape of the electrodeposits depends on the deposition potential, concentration as well as on the temperature and the presence of acetic acid. Moreover, it is observed that, the rate of the electrodeposition process is increasing during passing the time at the deposition potential range from −0.7 to -1 V, but decreases at the Ed -0.5 V. it is concluded that the electroreduction of molybdate ions occurs into two steps. After −0.7 V the electroreduction process of molybdate is accompanying with evolution of hydrogen.

Ref : 313
Title : Theoretical study of the clusters (ZnO) 6; X=O, S, Se, Te by using DFT and TDDFT
Author(s) :
Name : Nour El Houda BENSIRADJ
Address : école normale supérieur des enseignants,Kouba,alger,algérie
   
Accepted : 6/19/2016 6:46:00 AM    
Abstract :
The nano clusters of ZnX (X : O, S, Se, Te) are widely used in various industries such as rubber vulcanization, pharmaceutical productions and optoelectronic techniques. The development of new nanostructures of ZnX represents a great opportunity to create new materials for important applications such as the manufacture of solar cells, which are one of the promising renewable energy technologies for this century.In this work, we are interested to the theoretical study of a series of nanoclusters (ZnO) 6. We have selected three structures of clusters (ZnO) 6 with different symmetry, one planar C2h (form A), and the second three dimensional Cs (form B), and the last form C6v (form C).Calculation of the geometric parameters was carried out using the density functional theory (DFT) with functional B3LYP and the basis LANL2DZ.Concerning the excited states, the energy gap and oscillator strength were computed by TDDFT. We have represented emission and absorption spectrum properties as well as the transitions observed.
Our work has led us to significant results, especially for excited states which have a good process for application to materials in solar cells and optical applications that will be useful in the future theoretical and experimental scale.

Ref : 312
Title : Design, Synthesis, docking studies and in vitro antimicrobial activity of Some New 8-Hydroxyquinoline Derivatives that expected to have MurF inhibitory activity.
Author(s) :
Name : Sally Ismail Eissa
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azher University, Nasr City, Cairo, Egypt.
   
Name : Magda M. F. Ismail
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azher University, Nasr City, Cairo, Egypt.
   
Name : Heba. A. Rateb
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr University of science and Technology, Cairo, Egypt
   
Name : Dina El-Hussiny Abd El-Magid Lashin
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azher University, Nasr City, Cairo, Egypt.
   
Accepted : 6/19/2016 6:45:00 AM    
Abstract :
A series of some novel 8-hydroxyquinolin-5-sulfonyl derivatives were synthesized, docked into an active site of MurF to investigate their MurF binding affinity compared to the ligand. The docking results revealed that, compounds Vf , VI and VIIa,b,e,g interact with Asn 326, which is an amino acid involved in the mechanism of MurF inhibition; All new compounds (IV-XI) were tested for antimicrobial activity against strains of S. aureus, B. cereus, S. pneumonia, S. typhimurium, P. aeruginosa, E. coli, C. albicans and A. flavus at concentration 100µg/ml by agar-diffusion method. Tobramycin and fluconazole were used as reference standards for antibacterial and antifungal activities respectively. The potentially active compounds Vf, VI, VIIa, VIIb and VIIg were selected for testing minimum inhibitory concentration MIC (µg/ml). The compound revealed highest antibacterial activity was VIIb (MIC = 0.78 – 3.125 µg/ml), followed by VIIg (MIC = 1.56 – 12.5 µg/ml) then both Vf and VIIa (MIC = 1.56 – 25 µg/ml), finally compound VI with MIC = 3.125 – 25 µg/ml). For antifungal activity, Compounds VI, VIIa,b showed higher activity, compared to fluconazole, against C. albicans, where compounds VI, and VIIa,b,g were equipotent to fluconazole against A. flavus.

Ref : 311
Title : Utility of Some Carboxylic Acids in Preparation of Oxadiazole Derivatives Expected To Be Used As Anti-salmonella Typhi
Author(s) :
Name : Eid Eissa Salama Mohamed
Address : Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.
   
Accepted : 6/18/2016 9:25:00 AM    
Abstract :
Typhoid is a bacterial infection due to Salmonella typhi that causes symptoms. Symptoms may vary from mild to severe and usually begin six to thirty days after exposure.
This work concerned with utility of some carboxylic acids in heterocyclic synthesis, particularly those containing the 1,3,4-oxadiazole ring. Thus, 5-(4\-bromobenzyl)-1,3,4-oxadiazole-2-amine (I) and 5-(3\-nitrophenyl)-1,3,4-oxadiazole -2-amine (II) have been selected. Acylation cyclization and coupling with amino acids of the synthesized oxadiazoles are the main objectives in this study. All compounds were screened for their antibacterial activity against gram negative bacteria viz. Salmonella typhi where most of them have high antibacterial activity to most of the bacteria under investigation. The structures of the synthesized compounds were confirmed by IR, mass, 1H NMR and 13C NMR spectroscopy.
By the study of biological activity of the synthesized compounds, we recommend that compounds III, IV, VI, VII and VIII could be used as active antibacterial pharmaceuticals against gram negative bacteria Salmonella typhi where they have high activity against above bacteria and produced with good yield.

Ref : 310
Title : A facile synthesis and anticancer evaluation of new heterocycles incorporating oxindoline moiety
Author(s) :
Name : Hany I. Mohamed
Address : Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
   
Name : Mohamed M. H. Arief
Address : Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
   
Name : Aly A. Aly
Address : Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
   
Name : Ahmed A. Khalil
Address : Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
   
Accepted : 6/18/2016 5:48:00 AM    
Abstract :
A variety of heterocyclic compounds namely; triazoles, imidazoles, thiazoles, and oxazoles incorporating oxindoline moiety were synthesized via the in situ utilization of the highly reactive intermediate 4-(isatin-3-ylideneamino)benzoyl isothiocyanate. This intermediate was subjected to react with various nitrogen, sulphur and oxygen nucleophilic reagents to afford such heterocycles. The chemical structures of the synthesized compounds were elucidated based on elemental and spectral (FT-IR, NMR and MS) analyses. Anticancer activity was investigated and most of the tested heterocycles exhibited excellent activity against breast cancer cells.

Ref : 309
Title : Microwave-assisted synthesis of nanocrystalline LaCoO3 perovskite: Phase formation, characterization and catalytic activity studies
Author(s) :
Name : Rabei M.Gabr
Address : Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
   
Name : Maher M. Girgis
Address : Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
   
Name : Ahmed M.El-Awad
Address : Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
   
Name : Rasha M.K.Mohamed
Address : Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
   
Accepted : 6/17/2016 10:49:00 AM    
Abstract :
Combustion synthesis method was applied for LaCoO3 production, with a view to boosting its activity towards the dehydrogenation and/or dehydration reaction pathways of 2-propanol. With a highly exothermic and self-sustaining reaction, this perovskite was quickly prepared via sol-gel auto-combustion method using citric acid as a combustion complexing agent. Calcination was adopted in the temperature range 400- 800ºC in a dynamic air atmosphere. XRD analysis showed the formation of the nanostructure rhombohedral phase. The particle size and pore structure were determined from the XRD data and analysis of the adsorption isotherms of N2 at 77K. The results were supported by SEM and TEM examinations. TGA and DTA analysis revealed a sharp exothermic peak around 358ºC and a gradual weight loss up to ~ 600ºC. Dehydrogenation/ dehydration pathways of 2-propanol processed via the redox couple in the perovskite. The dehydrogenation was the predominant pathway forming acetone. A good correlation between the dehydrogenation selectivity and the evaluated redox couple species were established. A possible reaction mechanism consistent with the data obtained was proposed.


Ref : 308
Title : Acid and Enzymatic Saccharification of Waste Agricultural Biomass for Biotechnological Production of Xylitol
Author(s) :
Name : Abdul Ghaffar
Address : Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, 38000, Pakistan
   
Name : Bushra Munir
Address : Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, 38000, Pakistan
   
Name : Muhammad Yameen
Address : Department of Applied Chemistry and Biochemistry, Government College University, Faisalabad, 38000, Pakistan
   
Accepted : 6/16/2016 6:49:00 AM    
Abstract :
The plant biomass and agro-industrial wastes show great potential for their use as substrate in biotechnological processes and are attractive alternatives due to their low cost. Wheat straw and corn cob as hemicellulosic substrates were acid hydrolyzed and enzymatically saccharified for high xylose production in the liquor. The hydrolysate was concentrated and fermented by using a pentose fermenting yeast and hexose fermenting yeast for production of xylitol and ethanol in 48 h. The acid treated wheat straw and corn cob residue after enzymatic saccharification was treated with yeast. The maximum yield of xylitol from wheat straw and corn cob hemicellulosic hydrolysate was 65.561 g/L and 87.716 g/L and volumetric productivity of 0.014 g/L/h and 0.018 g/L/h, respectively by pentose fermenting yeast at 37 °C. Wheat straw and corn cob hemicellulosic hydrolysate produced xylitol 83.578 g/L and 41.282 g/L and volumetric productivity of 0.017 g/L/h and 0.009 g/L/h, respectively, under same conditions in fermentation by hexose fermenting yeast. On the other hand a low amount of ethanol was also produced in wheat straw hemicellulosic hydrolysate treated with both the yeast. The acid treated wheat straw and corn cob residue after enzymatic scarification and yeast fermentation under pH 7 and 6) gave xylitol yield of 85.242 g/L and 31.003 g/L and volumetric productivity of 0.018 g/L/h and 0.007 g/L/h under pH 7 while on the other hand under pH 6 it give xylitol yield of 89.810 g/L and 18.544 g/L and volumetric productivity of 0.019 g/L/h and 0.004 g/L/h respectively, by adopting same fermenting conditions using yeast. This xylitol production encourages the use of agro-industrial wastes for production of valuable products with medicinal use, food and sweets.

Ref : 307
Title : Design, Synthesis, Anti-inflammatory and Antimicrobial activities of Some New Pyridine-fused Tetracyclic Compounds Derived from Substituted Thieno[2,3-b]pyridines
Author(s) :
Name : Perihan A. Elzahhar
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
   
Name : Soad A. El-Hawash
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
   
Name : Raafat Soliman
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
   
Name : Alaa A. El-Tombary
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
   
Name : Salwa Elkazaz
Address : Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt
   
Accepted : 6/15/2016 3:07:00 PM    
Abstract :
Endeavors to discover an ultimate medication to treat inflammatory conditions such as rheumatoid arthritis and osteoarthritis continues to be an important drug design challenge (1). Furthermore, inflammation may cause accumulation of fluid in the injured area, which may promote bacterial growth (2). Besides, single molecule acting on multiple targets is considered as better drug candidate compared to drug combinations (3). Therefore, this work highlights design, synthesis and SAR of a novel series of pyridine derivatives to be investigated for their anti-inflammatory, analgesic and antimicrobial activities. Such series was derived from 4-(3,4-dimethoxyphenyl)-2-thio-6-(pyridin-3-yl)-1,2-dihydropyridine-3-carbonitrile (1) (4), which underwent Thorpe-ziegler isomerization with chloroacetonitrile to afford the 3-aminothieno[2,3-b]pyridine-2-carbonitrile (2). The latter was then reacted with ethylenediamine in the presence of carbon disulfide to afford the key intermediate 3 which was then cyclized into a number of tetracyclic derivatives (4-9). Most of the target compounds exhibited significant in vivo acute and chronic anti-inflammatory, analgesic and antimicrobial activities compared to the reference drugs. The synthetic procedures adopted to obtain the target compounds are illustrated in the following scheme.

References:
1-P. Rao, E.E. Knaus, J. Pharm. Pharm. Sci. 11 (2008) 81s-110s.
2-R. K. Tonk, S. Bawa, G. Chawla, G. S. Deora, S. Kumar, V. Rathore, N. Mulakayala, A. Rajaram, A. M. Kalle, O. Afzal, Eur. J. Med. Chem. 57 (2012) 176-184.
3-S. K. Suthar, V. Jaiswal, S. Lohan, S. Bansal, A. Chaudhary, A. Tiwari, A. T. Alex, A. Joesph, Eur. J. Med. Chem. 63 (2013) 589-602.
4-P. A. Elzahhar; Ph.D. Dissertation, Alexandria University (2015).

Ref : 305
Title : Removal of Cd(II) ions From Aqueous Solution using Nano sized Moringa Oleifera
Author(s) :
Name : Mallak Megalea Zikry
Address : Medicinal and Aromatic Plants Researches Department, Horticulture Research Institute (HRI), Agri. Res. Center (ARC), Giza, Egypt.
   
Name : Ahmed M. Abu-Dief
Address : Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt
   
Name : Laila H. Abdel-Rahman
Address : aChemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt
   
Name : M. A. Abd- El Sayed
Address : Medicinal and Aromatic Plants Researches Department, Horticulture Research Institute (HRI), Agri. Res. Center (ARC), Giza, Egypt
   
Accepted : 6/15/2016 2:16:00 PM    
Abstract :
This research aims to study the effect of nano sized Moringa oleifera on adsorption of Cd2+ ions from aqueous solution. Biosorbents was characterized by FTIR, SEM, TEM, XRD and EDS techniques. The influence of pH, temperature, adsorbent dosage, contact time, metal ion concentration and chemical treatment of biomass were investigated. The maximum capacity (qm) of Cd2+ ions biosorption by Moringa oleifera was 40.53 mg g−1. The removal efficiency was 93.74 % . The amount of Cd2+ ions adsorbed increases with increasing in adsorbent dosage and metal ion concentration. Biosorption of Cd2+ ions slightly increases as increasing the temperature. IR data showed that the main functional groups are responsible for Cd2+ ions binding in the biosorption process. Thermodynamic studies confirmed that the biosorption process is endothermic and the positive value of ΔG° indicated that the ion-exchan¬¬ge mechanism applies in the biosorption. The sorption process was fitted to pseudo second order kinetics. The Freundlich isotherm has a agood fit with the experimental data compared to Langmuir isotherm. This research observed that Moringa oliefera is available agricultural, low cost, environment friendly biosorbent for the removal of metal ions from aqueous environment.

Ref : 304
Title : photoodegradation of penachlorophenol and dimethoate on loam soil , sediment and spinach leaf surface in kenya
Author(s) :
Name : Ajuliu patrick kinyua
Address : P. o. box 215 Chuka 60400
   
Name : JAMES MBUGUA
Address : UNIVERSITY OF NAIROBI
   
Name : DR.JOYCE G.N. KITHURE
Address : UMIVERSITY OF NAIROBI
   
Name : PROFFESOR GEOFFREY KAMAU
Address : UNIVERSITY OF NAIROBI
   
Name : PROFFESOR L.W. NJENGA
Address : UNIVERSITY OF NAIROBI
   
Accepted : 6/15/2016 8:06:00 AM    
Abstract :
Photo-degradation of Pentachlorophenol and dimethoate on spinach leaf surface by incandescent and fluorescent light were studied. The study involved, spraying the standard pesticide solutions on 5cm by 5cm spinach leaf obtained from Ngara market before exposing to 40w, 60w, 75w and 100W incandescent bulbs and 9w, 11w, 15w and 20w fluorescence tube for 10, 20, 30, 60 and 120 minutes. The remaining residues level was determined by Shimadzu UV-Visible spectrophotometer at 322nm and 229nm for Pentachlorophenol and Dimethoate respectively.
The results obtained indicate that the photo-degradation of pesticide residue depends on light intensity, temperature, pesticide molecular structure and time of exposure. The rate constant ranged from 0.0091 to 0.0116 for dimethoate and 0.046 to 0.069 for pentachlorophenol. The rate of degradation was highest during the first 8 minutes of exposure platooning after 20minutes. The degradation was highest for incandescent bulbs. This explained by the fact that they emit both light and heat. It was highest in 100W due to the high number of photons responsible for chemical reaction. The residues breakdown followed 1st order kinetics.

Key words: photo-degradation, pentachlorophenol, dimethoate, kinetic, rate


Ref : 303
Title : Preparation and characterization of activated drinking water sludge/ TiO2 nanocomposite and its application for degradation of methylene blue under UV irradiation and UV with H2O2
Author(s) :
Name : M.Nageeb Rashed
Address : Chemistry Department, Faculty of Science, Aswan University, Egypt.
   
Name : M.A.E. Taher
Address : Chemistry Department, Faculty of Science, Aswan University, Egypt.
   
Name : Somaya M. M. Fadlalla
Address : Aswan Company for Water and Wastewater, Aswan, Egypt
   
Accepted : 6/14/2016 6:59:00 AM    
Abstract :
The main target of the present work is the preparation of activated drinking water sludge/ TiO2 nanocomposite (ADWS/ TiO2 ) by sol-gel method. Nanocomposite ADWS/ TiO2 was characterized and applied as a photocatalyst for degradation of Methylene Blue (MB) dye. Alum and Mud drinking water sludge were obtained from water treatment plants. The sludge was modified by nitric acid and pyrolysis at 700 oC to obtain new adsorbents. The composite was prepared at various ADWS /TiO2 weight ratio (1:1), (1:2) and (2:1). The photocatalystic degradation of Methylene Blue dye has been investigated using ADWS /TiO2 under UV irradation and UV with H2O2. Parameters such as composite dosage, initial dye concentration, reaction time, and solution pH were used to study the optimum conditions for Methylene Blue dye degradation. The results revealed that the highest MB dye degradation was found at (2:1) ratio of ADWS /TiO2. An almost complete degradation was at 4 hours reaction time, solution pH7, 50 ppm initial dye concentration and 0.125 gm composite dose. The degradation removal efficiency of MB were 95.7% and 91.8% for Alum and Mud sludge composite, respectively under UV, while under UV with H2O2 the degradation efficiency were 99.8% and 97.9% for Alum and Mud composite, respectively. The kinetics study found that the photodegradation of Methylen Blue with the nano composite of ADWS /TiO2 follows the first order kinetic.

Ref : 302
Title : Adsorption of Methylene Blue using Modified Adsorbents from Drinking Water Treatment Sludge
Author(s) :
Name : M. Nageeb Rashed
Address : Chemistry Department, Faculty of Science, Aswan University, Egypt
   
Name : M.A. El Taher
Address : Chemistry Department, Faculty of Science, Aswan University, Egypt
   
Name : Somaya M. M. Fadlalla
Address : Aswan Company for Water and Wastewater, Aswan, Egypt
   
Accepted : 6/14/2016 6:39:00 AM    
Abstract :
This study aims to explore preparation of adsorbents from alum sludge (AS) and mud sludge (MS) of drinking water treatment plant, and its application to remove methylene blue (MB) dye from aqueous solution. The sludge (MS and AS) were treated by chemical and physical activation to obtain new adsorbents. Adsorption experiments were carried out under different conditions of initial dye concentration (50-60-75-100 mg\L), adsorbent dosage (0.05-0.1-0.25 gm), solution pH (3-5-7-9), temperature (20-40-60 oC) and contact time (20-40-60-90 min). The results show that activation sludge by nitric acid (0.25M HNO3) and the pyrolysis at 700 oC were selected as the optimum chemically and physically activated adsorbents. The optimum conditions for maximum adsorption of MB are 100 ppm initial dye concentration, 1 hour contact time, 25 oC solution temperature, pH 7 and 0.25 gm adsorbent dosage. Application of Langmuir and Freundlich Isotherm models revealed that adsorbents fitted well the Langmuir model. SEM studies indicated the porous structural aspects of sludge suitable for removing methylene blue dye.

Ref : 301
Title : Synthesis and study of Ruthenium complexes of some benzotriazole derivatives and their biological effect
Author(s) :
Name : Hemmat A.Elbadawy
Address : alexandria
   
Name : Ayman A. abdelaziz
Address : cairo
   
Name : Madeha O.I.Ghobashy
Address : Tabuk , KSA
   
Accepted : 6/14/2016 6:04:00 AM    
Abstract :
A new air stable low spin Ru(III) complexes have been synthesized, from the reaction of 2-(2-p-X-phenylhydrazono)-2-(1H-benzo[1,2,3]triazol-1-yl)-1-phenylethanone , X=H,F, Cl, Br, NO2,OCH3 and CH3 with RuCl3.3H2O in ethanol in presence of KOH in the media. The resulted complexes are studied by elemental analysis, molar conductivity, thermal analysis magnetic and spectral (UV-Vis., FTIR, EPR) studies. The redox behavior of the complexes is investigated by cyclic voltammetry method. The magnetic and spectral studies showed that binuclear structure of the complexes in the general form of [Ru2(L)4Cl2].nH2O. Some antibacterial activities of the ligands and their complexes have also been studied.

Ref : 300
Title : PREPARATION AND IN VITRO EVALUATION OF RESEALED ERYTHROCYTES AS A NEW TREND IN TREATMENT OF ASTHMA
Author(s) :
Name : Mohammed F. Ibrahim
Address : Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
   
Name : Alaa Zaky
Address : Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
   
Name : Mohsen I. Afouna
Address : Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
   
Name : Ahmed M. Samy
Address : Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt.
   
Accepted : 6/13/2016 5:02:00 PM    
Abstract :
Carrier erythrocytes are emerging as one of the most promising biological drug delivery systems investigated in recent decades. Beside its bio-compatibility, biodegradability and ability to circulate throughout the body, it has the ability to perform extended release system of the drug for a long period. The ultimate goal of this study is to introduce a new carrier system for Salbutamol, maintaining suitable blood levels for a long time, as atrial to resolve the problems of nocturnal asthma medication Therefore in this work we study the effect of time, temperature as well as concentration on the loading of salbutamol in human erythrocytes to be used as systemic sustained release delivery system for this drug. After the loading process is performed the carrier erythrocytes were physically and cellulary characterized. Also, the in vitro release of salbutamol from carrier erythrocytes was studied over time interval.
From the results it was found that, human erythrocytes have been successfully loaded with salbutamol using endocytosis method either at 25 Co or at 37 Co. The highest loaded amount was 3.5 mg/ml and 6.5 mg/ml respectively. Moreover the percent of cells recovery is 90.7± 1.64%. Hematological parameters and osmotic fragility behavior of salbutamol loaded erythrocytes were similar that of native erythrocytes. Scanning electron microscopy demonstrated that the salbutamol loaded cells has moderate change in the morphology. Salbutamol releasing from carrier cell was 43% after 36 hours in phosphate buffer saline. The releasing pattern of the drug from loaded erythrocytes showed initial burst release in the first hour followed by a very slow release, obeying zero order kinetics. It concluded that salbutamol is successfully entrapped into erythrocytes with acceptable loading parameters and moderate morphological changes, this suggesting that erythrocytes can be used as prolonged release carrier for salbutamol.

Ref : 299
Title : Utility of 2-cyano-N-(furan-2-ylmethyl)acetamide for synthesis and characterization of some new thiazole, bithiazolidinone and pyrano[2,3-d]thiazole derivatives as potent antimicrobial agents
Author(s) :
Name : Mohamed Abdelrashid Salem
Address : Chemistry Department, Faculty of Scince, Alazhr University
   
Accepted : 6/12/2016 8:04:00 PM    
Abstract :
In an attempt to find a new class of antimicrobial agents, a series of thiazole, bithiazolidinone and pyranothiazole derivatives containing furan moiety were prepared via the reaction of 2-cyano-N-(furan-2-ylmethyl)-acetamide (1) with appropriate electrophilic reagents. These compounds were screened for their antibacterial activity against Gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis and Bacillis subitilis), Gram-negative bacteria (Pseudomonas aeruginosa, Proteous vulgaris and Klebsiella pneumonia) and antifungal activity against (Aspergillus fumigatus, Aspergillus clavatus and Geotricum candidium). Among the synthesized compounds, thiazole derivatives 27a and 27b were equipotent to gentamycin against K. pneumonia (MIC 0.49µg/mL), and showed in vitro antifungal activity equipotent to amphotericin B versus A. fumigatus (MIC 0.98µg/mL), A. clavatus (MIC 0.98µg/mL) and G. candidium (MIC 0.49µg/mL). Also, Bithiazolidinon-es 18 and 19 were equipotent to amphotericin B in inhibiting the growth of A. clavatus (MIC 0.98µg/mL) and G. candidium (MIC 0.49µg/mL). Structures of the newly synthesized compounds were established by elemental analysis and spectral data.

Ref : 298
Title : Novel Hybrid Quinazoline-Thiazolidinone Derivatives: Design, Synthesis, and in Vitro Anti-inflammatory Activity
Author(s) :
Name : Associate Prof. Yaser A. El-Badry
Address : Organic Chemistry Lab, Faculty of Specific Education, Ain Shams University, 11566 Abbasseya, Cairo,Egypt.
   
Accepted : 6/12/2016 6:02:00 AM    
Abstract :
At the present study, a novel series of quinazolinone-thiazolone derivatives bearing vinyl thienyl moiety at the 2 position has been synthesized with the aim of curring multi-drug resistant problems. The quinazoline and styryl thiazolidinones 4 have been clubbed through ethyl linkage to get hybrid molecules 6-13. The structure of the newly synthesized compounds was elucidated using elemental and spectral analysis like FT-IR, 1H NMR, 13C NMR, and HR-Ms.
The anti-inflammatory activity of all the newly synthesized compounds was evaluated using the carrageenan-induced paw oedema test in rats using indomethacin as the reference drug. Compounds 8, 11, and 12 were the most active compounds, showing an activity comparable to indomethacin.

Ref : 297
Title : Soybean Oil-Based Highly Branched Polyester Resins
Author(s) :
Name : Prof Dr Kamal I Aly
Address : Polymer Research Laboratory, Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
   
Accepted : 6/12/2016 6:05:00 AM    
Abstract :
Highly branched polyester resins (HBPERs) with different amounts of trimellitic anhydride (B3 monomer) and pre-polyester diol (A2 monomer) of soybean oil, phthalic and maleic anhydrides have been synthesized. The effect of branching of the synthesized polyester resins on physical properties such as acid values, saponification values, iodine values, etc. and morphological characteristics have been studied. All the (HBPERs) were soluble in common organic solvents like halogenated solvents, alcohols, DMF, DMSO, etc. The morphological properties (SEM and TEM) of (HBPERs) were detected.

Keywords : Highly branched polyester; Soybean oil; Performance characteristics; Morphological behavior.

Ref : 296
Title : Artificial Zinc(II) Tweezers Relevant to the Modelling of N-Ada DNA repair protein
Author(s) :
Name : Mohamed M. Ibrahima
Address : a Chemistry Department, Faculty of Science, Kafr El-SHeikh University, Egypt; bChemistry Department, Faculty of Science, Taif University, KSA
   
Accepted : 6/11/2016 9:52:00 AM    
Abstract :
In the biological system, The N-terminal domain of E.coli Ada protein repairs methyl phosphotriesters in DNA by direct, irreversible transfer of the methyl group to one of its cysteines, Cys69 (Scheme 1). This methyl transfer results in irreversible loss of repair activity, hence N-Ada is not an enzyme in the true sense but instead is a sacrificial intracellular reagent for DNA repair4. This protein contains a zinc ion tightly bound to four cysteine residues, one of which is Cys69, the methyl acceptor. Alkylation occurs on Cys69, showing that this particular cysteine ligand is electronically activated relative to the other three cysteines. The thiolate sulfur atoms of Cys38, Cys42, and Cys72 are hydrogen-bonded to amide protons of the protein main chain, which suppresses not only their reactivity but also stabilizes the protein structure. On the other hand, the Cys69-S- is devoid of hydrogen-bonding interactions.
of As part of our studies in biomimetic zinc chemistry (1-5), we have started research program to understand how the nature of the bound thiolate coligand could affect the rate of thiolate methylation via (i) design, synthesis, characterization, structural properties and reactivity of several pseudo tetrahedral zinc thiolate complexes as structural and functional mimics for enzymes with this feature, such as N-Ada repair protein; (ii) How the structure of zinc thiolates is affected by the presence of intramolecular hydrogen-bonding interactions. The results of this work may aid in our understanding of the mechanism of alkyl group transfer in metalloenzymes.

References

1. M. M. Ibrahim, G. A. M. Mersal, N. El-Shafai, M. Youssef, H. Shokry, Comptes rendus chimie 17 (2014) 1013-1022.
2. M. M. Ibrahim, S. Y. Shaban, Inorganica Chimica Acta, 362 (2009) 1471-1477.
3. M. M. Ibrahim, S. Y. Shaban, K. Ichikawa, Tetrahedron lett.. 49(2008) 7303–7306.
4. M. M. Ibrahim, C. P. Olmo, T. Tekeste, J. Seebacher, G. He, J. A. M. Calvo, K. Böhmerle, G. Steinfeld, H. Brombacher, H. Vahrenkamp, Inorg. Chem. 45 (2006) 7493-7502.
5. M. M. Ibrahim, J. Seebacher, G. Steinfeld, H. Vahrenkamp, Inorg. Chem. 44 (2005) 8531-8538.

Ref : 295
Title : Synthesis of New Pyridothienopyrimidinone Derivatives as Pim-1 Inhibitors
Author(s) :
Name : Hala Bakr El-Nassan
Address : Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
   
Name : Bassem Heshmat Naguib
Address : Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo 11837, Egypt
   
Accepted : 6/11/2016 8:19:00 AM    
Abstract :
Pim kinases are a class of constitutively active serine/threonine kinases (1). Pim kinases are involved in many biological processes including cell survival, proliferation, metabolism and apoptosis (2). Overexpression of pim-1 and pim-2 were reported in hematologic cancers as well as solid cancers (2). Therefore, targeting pim kinases may represent a promising strategy to fight cancer. In 2012, Tsuhako et al. (3) reported the discovery of 2-aryl and 2-alkyl benzofuropyrimidinones (I, II, Fig 1) as potent and selective pim-1 inhibitors. In this work, both 2-aryl and 2-alkylpyridothienopyrimidin-ones (III, IV, Fig 1) were designed and synthesized as bioisosteres to benzofuropyrimidinones I. All the compounds were tested for their pim-1 inhibitory activity. Six of the compounds showed potent pim-1 inhibition (81-98% inhibition). The 2-triflouromethyl derivative showed 96% inhibition, while the 2-(2-triflouromethylphenyl)-2,3-dihydro derivative exhibited 98% inhibition of the enzyme. The anticancer screening of the compounds is currently under investigation.

Figure 1. Structures of the lead compounds and the synthesized compounds I-IV.
References
1. D. Drygin, et al., J. Med. Chem. 55 (2012) 8199-8208.
2. G. M. Arunesh, et al, Expert Opin.Ther. Patents 24 (2014) 5-17.
3. A. L. Tsuhako, et al, Bioorg. Med. Chem. Lett. 22 (2012) 3732–3738.

Ref : 294
Title : Conversion of Agricultural Residues into Nano−Porous Activated Carbons
Author(s) :
Name : Prof. Kamal Mohamed Sayed Khalil
Address : Chemistry Department, Faculty of Science,Sohag University, Sohag 82524,Egypt
   
Accepted : 6/10/2016 11:43:00 AM    
Abstract :
Activated carbons (ACs) are very effective adsorbents for many organics, inorganic metal ions, toxics and hazardous species. However, ACs are relatively expensive, due to limitation of their raw materials and high production cost. Therefore, introducing of new resources for AC production is very challenging. Among these new resources, agriculture residues are very valuable and interesting [1]. Moreover, conversion of agricultural residues into carbon containing materials helps community to get rid of agricultural residues and help climate change mitigation [2].
This contribution emphasizes the utilization of some agriculture residues as raw precursor materials for the formation of ACs. Conversion was preformed through an environmental method, which involves impregnation with ZnCl2 solution and followed by thermo chemical pyrolysis. The resulting activated carbons were characterized via a variety of techniques including elemental analysis, simultaneous thermal analysis, TG−DTA, attenuated total reflectance infra red spectroscopy, ATR−FTIR, and nitrogen gas adsorption/desorption. Results showed that high carbon contents, high specific surface area, and super−microporosity to mesoporosity were obtained for the ACs as function of their preparation parameters. Adsorption properties of the obtained ACs were examined towards cationic and anionic adsorbates. The performance of the ACs materials in adsorption from gas phase or solutions are presented. The promising utilization of the indicated ACs in purification and energy production application will be highlighted.
References:
[1] A. Kumar, H. Mohan Jena, Appl. Surf. Sci. 356 (2015) 753–761.
[2] M. Ahmad, A.U. Rajapaksha, J.E. Lim, M. Zhang, N. Bolan, D. Mohan, M. Vithanage, S.S. Lee, Y.S. Ok, Chemosphere 99 (2014) 19–33.

Ref : 293
Title : INCORPORATION OF PLASTIC WASTES IN ASPHALT DESIGN FOR ROAD PAVEMENT
Author(s) :
Name : Dr Moorey Dalen
Address : Department of Chemistry, Federal University Lafia, Nigeria
   
Name : Samuel Danladi Mador
Address : Department of Chemistry, University of Jos, Nigeria
   
Accepted : 6/10/2016 11:44:00 AM    
Abstract :
Plastics have become an indispensable part of our everyday life since their introduction over 100 years ago. Their versatility in application also brings associated disposability problem especially those that are used for packaging. Consequently, with growing public concern about environmental issues, plastic waste recycling and conversion offer a top shot solution. The recycling of plastics that used to end up only at city landfills or incinerators is increasing around the world. Discarded plastic products and packaging make up a growing portion of municipal solid waste (MSW). The United States Environment Protection Agency (EPA) estimated that the amount of plastics throw away is 50 % greater in the twenties than at the beginning of the 1990s and that plastic waste accounts for about 40 % of all wastes discharged into the streams while in Nigeria wastes plastics accounts for about 60% of municipal solid wastes. Fortunately, over the past two decades, recycling of plastics has dramatically increased (Modern Plastic (Encyclopedia Oct. 1990). This research provides an asphalt design for wearing course in road pavement where plastic wastes will be utilized along-side bitumen as binder in the asphalt. Each plastic waste type (PET, HDPE, PVC, LDPE, PP and PS) is to be blended with bitumen in percentages ranging from 5, 10,15,20,25 and 30 by weight of total binder required and the design tested for performance (to include: Marshall Stability and flow, voids in total mix, voids in mineral aggregate and voids filled with bitumen).Two designs which gave better performance results of the plastic modified asphalt (PMA) was blended in ratios 30:70, 40:60, 50:50, 60:40 and 70:30 and tested for performance to choose the best blending ratio. The design with the best performance result was used for a practical road pavement.

Ref : 292
Title : Phytoremedatiotion of Heavy and Trace Element in Heglieg oil field
Author(s) :
Name : Salma Abdelghaffar Hassan Alamin, Alawia Abdalla ELawad, Imad-eldin Ahmed Ali Babiker and Osman Mirghani Mohamed Ali
Address : Ministry of Education and Scientific Research. The National Center for Research Environmental and Natural Resources and Desertification Research Institute, Sudan
   
Accepted : 6/9/2016 6:43:00 AM    
Abstract :
The method used for the determination of elements was the atomic absorption. One g of air dried plant leaves from: Acaia seyal. Khaya senegalensis, Eucalyptus camaldulensis, Ophiuros exaltatus, sieved plants samples were placed into a furnace for 4 hours for dry ashing. The ash was kept in an Erlenmeyer flask extracting solution and 5ml (1M HCl) were added and the mixture was then placed in a filter paper into a 50- ml with extracting solution.
The results showed that concentrations Ca, Mg in Heglieg* oil field were high, and it were significantly different from control plants. Similarly concentrate K, Na, Zn, Fe, Cu and Mn concentrations in Heglieg oil field were low, and were significantly different from control, while Cr, Co, Cd and Pb were not detected.

*Heglieg oil field is located in the high wood land savanna zone in Western Kordofan State latitude 9.5958N , 9.99944°N longitude 29.23E, 29.39861°E

Ref : 291
Title : Electrical Properties on hexamine charge transfer complexes
Author(s) :
Name : Asmaa Abd El-Aziz Ibrahim
Address : Fculty of science, Aswan University
   
Accepted : 6/9/2016 5:45:00 AM    
Abstract :
Structural, electrical conductivity and thermal stability of charge-transfer (CT) complexes formed from the reaction between 4-hydroxy- benzaldehyde and 3,5-dinitrobenzoic acid as π- acceptors with hexamine. Elemental analysis (CHN), thermal analysis, x-ray and IR spectrum were used to characterize the new products. The data obtained refer to 1:2 (donor:acceptor) charge-transfer complexes being formed, The interaction between the donor and acceptor molecules takes place through the n–* and π-π* interaction. The electrical conductivity on charge transfer complexes studied at different temperatures, the rate constant (k) and activation energy were determined.


Ref : 290
Title : Monitoring Pesticide Residues in Soils and Groundwater in Algeria
Author(s) :
Name : Kahina AIT HAMMI
Address : Department of Chemistry, Laboratory of Materials Chemistry, University of Oran 1, BP 1524 El-M’Naouer, Oran, Algeria.
   
Name : Maria Dolores URANA AMATE
Address : Department of Chemistry and Physics, Agroalimentary Campus of International Excellence, ceiA3, University of Almeria, 04120, Almeria, Spain.
   
Name : Maria del Mar SOCIAS VICIANA
Address : Department of Chemistry and Physics, Agroalimentary Campus of International Excellence, ceiA3, University of Almeria, 04120, Almeria, Spain.
   
Name : Hafida MILOUDI
Address : Department of Chemistry, Laboratory of Materials Chemistry, University of Oran 1, BP 1524 El-M’Naouer, Oran, Algeria.
   
Name : Karima BAGHDAD
Address : Department of Chemistry, Laboratory of Materials Chemistry, University of Oran 1, BP 1524 El-M’Naouer, Oran, Algeria.
   
Accepted : 6/5/2016 10:32:00 AM    
Abstract :
The Oran region, located at Norwest of Algeria, concentrates the major agricultural activities and as a consequence, the scarce water resources are contaminated [1]. Furthermore, most of the farming soils in this region show low organic matter (OM) contents, reason which justifies the high fertilizers consumption and the addition of peat as an amendment. Taking into account that pesticide adsorption in soils is one of the main factors which control the transformations of these compounds in the environment and the effectiveness of their application, the present study addresses the effect of the use of a commercial peat as organic amendment in the adsorption process of flusilazole in two soils from the region of Oran.
The Kf values obtained from the fit of experimental data to the Freundlich model (Table I) showed that for all the soils studied, flusilazole molecules had a higher affinity for the surface of the soils as the percentage of peat used in the amendment increased. The important role of the OM was also confirmed by the good correlation existing between the KOC values and the percentage of OM of the soils [2]. The different behaviour of the sample 2 could be justified if we take into account its lower clay content. In the original soil, the organic matter could form clay-humic complexes which could facilitate the interaction with the flusilazole molecules. The addition of exogenous OM disturbs this adsorption mechanism, then decreasing the retention capacity of the sample 2. This fact is confirmed by the lower values of KOC obtained for the amended soils. The study of the adsorption-desorption process in the original and amended soils indicated a high hysteresis degree in all cases, the Kf desorption parameter being much higher than Kf adsorption, thus confirming the irreversibility of the flusilazole adsorption process and therefore, its low pollution potential.
The study of the adsorption-desorption process of flusilazole in the Algerian soils indicated that the organic amendment improves, in general, the adsorption capacity of these soils, decreasing the possibility of leaching and reducing the risks of groundwater contamination.
References

[1] S. Maas, R. Scheifler, M. Benslama, N. Crini , E. Lucot, Z. Brahmia, S. Benyacoub and
P. Giraudoux, Environ. Pollut., 158(6), (2010) p.2294.
[2] M.C. Fernández, L. Cox, M.C. Hermosín, J. Cornejo, Pest Manag. Sci., 62(12), (2006) p.
1207.

Ref : 287
Title : Photoinduced Electron Transfer Mechanism for Photodegradation of Eriochrome Black T by ZnO Nanoparticles
Author(s) :
Name : Ibrahim El-Mehasseb
Address : Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt.
   
Name : Hany El-Shamy
Address : Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt.
   
Name : Hamdy S. El-Sheshtawy
Address : Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt.
   
Name : Maged El-Kemary
Address : Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, 33516 Kafr ElSheikh, Egypt.
   
Accepted : 6/4/2016 11:44:00 AM    
Abstract :
Efficient Photodegradation of Eriochrome black T (EBT) by hexagonal ZnO nanoparticles was investigated under illumination of UV-Visible light (365 nm) [1, 2]. The photodegradation process occurs by both electron/holes charge separation and photoinduced electron transfer process from the dye (EBT) to the nanocrystal (ZnO). The photodegradation process was mainly occurs due to the electrons in the conduction bands rather than hydroxyl radical. ZnO nanoparticles were prepared by wet chemical method and characterized by different techniques. The optical properties of ZnO NPs were investigated by UV–Vis and fluorescence spectroscopy. The results show that the average particle size was ~39.7 nm with a band gap of 2.94 eV. The degradation kinetics follows a pseudo-first-order mechanism and increases in the order pH 11.2 > 7.1 > 3.02.
References
[1] M. El-Kemary, M. Gaber, Y. El-Sayed, Y. Gheat, J. Lumin. 159 (2015) 26.
[2] M.E. El-Khouly, M.A. El-Kemary, S. Fukuzumi, J. Photochem. Photobiol. A Chem. 302 (2015) 11.

Ref : 286
Title : Glycine Capped SnO2 Nanoparticles: Synthesis, Photophysical Properties and Photodegradation Efficiency
Author(s) :
Name : H. S. El-Sheshtawy
Address : Nanotechnology Center, Chemistry Department, Faculty of Science, Kafrelsheikh University, Egypt
   
Name : S. R. Alharbi
Address : Physics Department, Science Faculty -Al Faisaliah Campus King Abdulaziz University, Saudi Arabia
   
Accepted : 6/4/2016 5:41:00 AM    
Abstract :
Simple, time efficient, and environmentally friendly Microwave-assisted approach towards the synthesis of glycine (GLY) capped SnO2 nanoparticles. Highly monodispersed GLY@SnO2 nanocrystals were obtained within 50 s of microwave irradiation. The structure of GLY@SnO2 investigated by different spectroscopic techniques. The average size of SnO2 was calculated to be 5.2 nm by different spectroscopic techniques.
Photophysical properties of GLY@SnO2 NPs were explored by UV–visible, and fluorescence spectroscopy. The synthesized nanoparticles were used in photocatalytic degradation of Nile blue (NB) dye. The photocatalytic degradation attributed to the separation of the photogenerated holes and electrons.
References
1- El-Sheshtawy H. S., Abd El Sadek M. S., Yahia I. S., Nanosci. Nanotechnol. Lett. 6 (2014) 18.
2- A. Bhattacharjee, M. Ahmaruzzaman, Materials Letters 139 (2015) 418.

Ref : 285
Title : Detection of coumarins for ten plants used in Ethnoveterinary medicine
Author(s) :
Name : Ahmed Abdelhafiz Alshikh, Ibrahim Fatah al-Rahman Ahmed, Najat Ahmed Alrofaei
Address : International University of Africa, Sudan
   
Accepted : 6/2/2016 6:25:00 AM    
Abstract :
The present study were detected of coumarins compounds in ten plant used in Ethnoveterinary medicine in Sudan, where it was the work of extracts of different plants parts using three solvents (ethanol, petroleum ether, chloroform). Phytochemical screening method and thin layer chromatography (T.L.C) used to detection of coumarins in those plants extracts have shown good results.

Ref : 284
Title : Conversion of Fructose to 5-Hydroxymethylfurfural catalyzed by a core-shell Fe3O4@SiO2-SO3H magnetic nanoparticles
Author(s) :
Name : El Barbary Hassan
Address : Box 9820, Mississippi State, MS 39762, United States
   
Name : Islam Elsayed
Address : Box 9820, Mississippi State, MS 39762
   
Accepted : 6/1/2016 12:56:00 PM    
Abstract :
Recently, magnetic nanoparticles based catalysts attracted more attention due to their good stability and easy separation from the reaction mixture by a permanent magnet. This research discuss the potential use of (Fe3O4@SiO2-SO3H) nanoparticles as catalyst for the dehydration of fructose into 5-hydroxymethylfurfural (HMF). A magnetically recoverable (Fe3O4@SiO2-SO3H) nanoparticles was successfully prepared by supporting sulfonic acid groups (SO3H) on the surface of silica-coated Fe3O4 nanoparticles. The prepared catalyst was characterized by FTIR, TGA, XRD, TEM and SEM analysis. The catalyst’s surface acidity was determined by acid-base titration. Dehydration of fructose was performed in a biphasic system made up of water and methylisobutylketone (water/MIBK), and the effect of various reaction parameters affecting on the yield of HMF such as biphasic system ratio, catalyst concentration, temperature, time, and dimethylsulfoxide (DMSO) ratio were studied. Fe3O4@SiO2-SO3H catalyst disclosed a great catalytic activity for the formation of HMF and fructose conversion. More than 70% yield of HMF and 95% fructose conversion were obtained at the optimum reaction conditions. At the end of the reaction, the catalyst was easily removed by magnet from the reaction mixture.

Keywords
Fructose; Dehydration; 5-Hydroxymethylfurfural; Magnetic nanoparticles; Fe3O4@SiO2-SO3H

Ref : 283
Title : Dry sliding wear of AZ31 and AZ31-5.6 wt. % Ti composite reinforced with nano-sized alumina particulates
Author(s) :
Name : Nariman E. Elbaly
Address : Mechanical Engineering Department, Faculty of Engineering-Helwan, Helwan University, Cairo, Egypt.
   
Name : Ayman Elsayed
Address : Powder Technology Lab.,Central Metallurgical Research & Development Institute, Cairo, Egypt
   
Name : Hoda Abdel-kader
Address : Mechanical Engineering Department, Faculty of Engineering-Helwan, Helwan University, Cairo, Egypt.
   
Name : Simo-Pekka Hannula
Address : Department of Materials Science and Engineering, School of Chemical Technology, Aalto University, Espoo, Finland.
   
Accepted : 5/31/2016 4:44:00 PM    
Abstract :
In this study, 5.6 wt.% Ti and nano-alumina (n-Al2O3) particles reinforcement were added to AZ31 magnesium alloy to improve the wear behavior under dry sliding conditions. The composites contain reinforcement of 5.6 wt.% Ti and 0.5 wt.%, 1 wt.% and 2 wt.% n-Al2O3.The compacts were manufactured by hot compaction technique at 475 °C. The sliding dry wear tests of the alloy and nanocomposite were carried out at room temperature using the standard ball- on- disc equipment under loads of 1N and 5N. The wear mechanisms of the worn out surface were studied using SEM analysis. The influence of test parameters on volume loss of the discs was studied. Results revealed that the coefficient of friction decreases as the load applied increases. Combination of 5.6 wt.% Ti and n-Al2O3 possessed hybrid effect on the wear performance of the composites. The influence of test parameters on volume loss of the discs was evaluated.

Ref : 282
Title : Investigation on wear properties of AZ31magnesium based hybrid nanocomposite through MWCNT addition processed by hot compaction technique
Author(s) :
Name : Nariman E. Elbaly
Address : Mechanical Engineering Department, Faculty of Engineering-Helwan, Helwan University, Cairo, Egypt.
   
Name : Ayman Elsayed
Address : Powder Technology Lab.,Central Metallurgical Research & Development Institute, Cairo, Egypt.
   
Name : Hoda Abdel-kader
Address : Mechanical Engineering Department, Faculty of Engineering-Helwan, Helwan University, Cairo, Egypt.
   
Name : Simo-Pekka Hannula
Address : Department of Materials Science and Engineering, School of Chemical Technology, Aalto University, Espoo, Finland.
   
Accepted : 5/31/2016 4:40:00 PM    
Abstract :

Alloy AZ31 is a magnesium alloy used for structural and transport applications. It contains aluminium and zinc as main alloying elements. Wear behavior of particle reinforced magnesium matrix composites play critical role for potential application in industries such as automotive and aerospace [1]. 5.6 wt.% Ti and carbon nanotubes (CNTs) reinforcements were added to AZ31 magnesium alloy to improve the wear behavior under dry sliding conditions. The composites of Mg alloy, AZ31 (Al 3%, Zn 1%, rest Mg) and AZ31-5.6 wt.% Ti nanocomposites reinforced with multi-wall carbon nanotubes (MWCNTs) were fabricated by hot compaction technique. Friction coefficient and wear loss under dry conditions was evaluated for the different compacts using ball-on-disc wear test apparatus at different applied loads of 1N and 5N. The surface topography and volume loss were recorded for all samples. The effect of varying percentages of MWCNTs on the wear properties of AZ31& AZ31-5.6 wt. % Ti composites was evaluated. Microstructural investigations on the worn surfaces were undertaken using a scanning electron microscope (SEM) for pointing out the wear mechanism. The results revealed that the coefficient of friction decreases as the applied load increases. The influence of test parameters on volume loss of the discs was evaluated.
References
1. L. Feray Guleryuz, S. Ozan, D. Uzunsoy and R. Ipek, ACTA PHYSICA POLONICA A, Proceedings of the 2nd International Congress APMAS2012, April 26-29, 2012, Antalya, Turkey

Ref : 281
Title : Highly Efficient Adsorbent for Uranium Removal from Aquatic Nuclear Wastes
Author(s) :
Name : Emad Elshehy
Address : Nuclear Materials Authority, 530 P.O. Box, El-Maadi, Cairo, Egypt
   
Accepted : 5/30/2016 2:06:00 PM    
Abstract :
This study focused on tailoring mesoporous silica monoliths to be used as highly sensitive adsorbent for simple and simultaneous removal processes of radioactive metal ions such as U(IV) ions from aquatic samples. The adsorbent is fabricated through functional immobilization of 3-glycidoxypropyltrimethoxysilane followed by organic ligand containing amino group into large, open, tube-pored, three-dimensional cubic mesostructures with micrometer-sized monolith particles. This simple strategy offered significant control over the pore connectivity and structural regularity of the cubic pm3m geometry. The potential functionalities of this uniformly sized cylinder cubic Pm3m materials show promise as the primary component in efficient separation systems that can satisfy technologigal needs as well, such as simplicity in fabrication design and separation functionality. The unique features of the adsorbent allow the removal and extraction of ultratrace concentrations of U(IV) ions. Based on our results, this new class of adsorbent exhibited long-term stability of removal and extraction functionalities of U(IV) ions that in general provided extraordinary sensitivity, selectivity, reusability, and fast kinetic removal of U(VI) ions in aquatic samples

Ref : 280
Title : Nanodiamomd Composite As Smart Coating for Textile Fabrics
Author(s) :
Name : Nour F. Attia
Address : Fire Protection Laboratory, Chemistry Division, National Institute for Standards, 136, Giza 12211, Egypt
   
Name : Hashem M. Salem
Address : Textile Department, Faculty of Engineering and Technological Industries, Sudan University for Science and Technology, Sudan
   
Name : Abeer A. Saleh
Address : Textile Department, Faculty of Engineering and Technological Industries, Sudan University for Science and Technology, Sudan
   
Accepted : 5/27/2016 2:57:00 PM    
Abstract :
Nanomaterials have attracted much of attentions due to their unique properties which demanded in various applications [1].Their use in textile finishing for imparting advanced functions for textile fabrics attracted many scientists [2]. In this study, novel nanodiamond based composites were developed for textile fibers coating. Developed coating layer improved the properties of the treated textiles. The dispersion and mass ratio of the composite were studied and optimized. The ultraviolet protection factor of the treated textile fibers was significantly enhanced achieved more than 3 fold increase compared to untreated fabrics. Furthermore, the mechanical and thermal properties of the treated fabrics were improved. The morphology of untreated and treated fabrics was characterized using scanning electron microscope.

References
[1]Nour F. Attia, J. P. Rao, Kurt E. Geckeler, Journal of Nanoparticle Research, 2014,16, 2361
[2] Nour F. Attia, Amal A. Abissy, Mohamed A. Hassan, Polymers for Advanced Technologies. 2015, 26,1551-1557

Ref : 279
Title : Utility of N-bromosuccinimide as an environmental-friendly reagent for simple spectrophotometric methods for the determination of two phosphodiesterase type 5-inhibitors in pure and dosage forms
Author(s) :
Name : Eman M. Hafez
Address : Chemistry Department, Faculty of Sciences, Zagazig University, Zagazig, 44519, Egypt